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Details on Person ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA

Class:IdReaction:548830
_displayNameELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA
_doReleaseTRUE
_timestamp2024-04-12 19:41:41
authored[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
catalystActivity[CatalystActivity:548824] fatty acid elongase activity of ELOVL1,4 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:548837] D'Eustachio, P, 2010-03-14
edited[InstanceEdit:699799] D'Eustachio, P, 2010-05-08
inferredFrom
input[SimpleEntity:548808] TCS-CoA [cytosol]
[SimpleEntity:29508] Mal-CoA [cytosol]
[SimpleEntity:70106] H+ [cytosol]
internalReviewed[InstanceEdit:9907566] D'Eustachio, Peter, 2024-04-12
isChimericFALSE
literatureReference[LiteratureReference:548665] Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids
[LiteratureReference:548675] Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4
modified[InstanceEdit:548844] D'Eustachio, P, 2010-03-14
[InstanceEdit:548845] D'Eustachio, P, 2010-03-14
[InstanceEdit:548851] D'Eustachio, P, 2010-03-14
[InstanceEdit:827349] Matthews, L, 2010-05-27
[InstanceEdit:5676204] Jassal, Bijay, 2015-02-19
[InstanceEdit:5678221] D'Eustachio, Peter, 2015-02-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
[InstanceEdit:9907565] D'Eustachio, Peter, 2024-04-12
[InstanceEdit:9907580] D'Eustachio, Peter, 2024-04-12
nameELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA
H(+) + malonyl-CoA + tetracosanoyl-CoA => 3-oxohexacosanoyl-CoA + CO2 + CoA
lignoceroyl-CoA + malonyl-CoA => 3-oxocerotoyl-CoA + CO2 + CoASH
output[SimpleEntity:548797] 3OHC-CoA [cytosol]
[SimpleEntity:76194] CoA-SH [cytosol]
[SimpleEntity:113528] CO2 [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2010-06-15
reviewed[InstanceEdit:5678222] D'Eustachio, Peter, 2015-02-21
[InstanceEdit:9907581] Hill, David P, 2024-04-12
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5676160] Jassal, Bijay, 2015-02-19
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104706] R-HSA-548830.3
structureModified[InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
summation[Summation:548835] Elongation of very long chain fatty acids proteins 1, 4 (ELO...
(hasEvent)[Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785512] Update Tracker - [Reaction:548830] ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA - v52:[modifyText]
[_UpdateTracker:9910991] Update Tracker - [Reaction:548830] ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA - v89:[addInput]
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