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Details on Person HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA

Class:Id	Reaction:548818
_displayName	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA
_doRelease	TRUE
_timestamp	2024-03-20 19:02:58
authored	[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
catalystActivity	[CatalystActivity:548828] very-long-chain 3-oxoacyl-CoA reductase activity of HSD17B3,12 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9644060] very-long-chain 3-oxoacyl-CoA reductase activity of HSD17B3,12 [endoplasmic reticulum membrane] Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:548837] D'Eustachio, P, 2010-03-14
edited	[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
input	[SimpleEntity:548812] 3OOD-CoA [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:196129] Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3 [LiteratureReference:548718] Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade
modified	[InstanceEdit:548844] D'Eustachio, P, 2010-03-14 [InstanceEdit:548845] D'Eustachio, P, 2010-03-14 [InstanceEdit:827349] Matthews, L, 2010-05-27 [InstanceEdit:5676204] Jassal, Bijay, 2015-02-19 [InstanceEdit:5678221] D'Eustachio, Peter, 2015-02-21 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
name	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + NADPH + H+ => 3-hydroxyoctadecanoyl-CoA + NADP+
output	[SimpleEntity:548836] 3HODC-CoA [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA [Homo sapiens] [Reaction:201035] ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:5678222] D'Eustachio, Peter, 2015-02-21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5676160] Jassal, Bijay, 2015-02-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104395] R-HSA-548818.4
summation	[Summation:548796] Hydroxysteroid (17-beta) dehydrogenase 12 (HSD17B12) catalyz...
(hasEvent)	[Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs [Homo sapiens]
(precedingEvent)	[Reaction:5676637] PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784912] Update Tracker - [Reaction:548818] HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA - v52:[addLiteratureReference, modifyText]
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