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Details on Person ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA

Class:Id	Reaction:548814
_displayName	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA
_doRelease	TRUE
_timestamp	2024-04-12 19:41:42
authored	[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
catalystActivity	[CatalystActivity:548801] fatty acid elongase activity of ELOVL3,6,7 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:548837] D'Eustachio, P, 2010-03-14
edited	[InstanceEdit:699800] D'Eustachio, P, 2010-05-08
input	[SimpleEntity:200993] PALM-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9907566] D'Eustachio, Peter, 2024-04-12
isChimeric	FALSE
literatureReference	[LiteratureReference:548743] Identification and characterization of a selective radioligand for ELOVL6 [LiteratureReference:5676201] Biochemical characterization of the very long-chain fatty acid elongase ELOVL7 [LiteratureReference:1660633] ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
modified	[InstanceEdit:548844] D'Eustachio, P, 2010-03-14 [InstanceEdit:548845] D'Eustachio, P, 2010-03-14 [InstanceEdit:827349] Matthews, L, 2010-05-27 [InstanceEdit:5676204] Jassal, Bijay, 2015-02-19 [InstanceEdit:5678221] D'Eustachio, Peter, 2015-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20 [InstanceEdit:9907565] D'Eustachio, Peter, 2024-04-12 [InstanceEdit:9907580] D'Eustachio, Peter, 2024-04-12
name	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH
output	[SimpleEntity:548812] 3OOD-CoA [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:201035] ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-06-15
reviewed	[InstanceEdit:5678222] D'Eustachio, Peter, 2015-02-21 [InstanceEdit:9907581] Hill, David P, 2024-04-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5676160] Jassal, Bijay, 2015-02-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105866] R-HSA-548814.3
structureModified	[InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
summation	[Summation:548840] The ER membrane-bound elongation of very long chain fatty ac...
(hasEvent)	[Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs [Homo sapiens]
(precedingEvent)	[Reaction:548818] HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA [Homo sapiens]
(replacementInstances)	[_Deleted:5676216] Deletion of instance: 548842 [_Deleted:5676220] Deletion of instance: 548825
(updatedInstance)	[_UpdateTracker:9785136] Update Tracker - [Reaction:548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA - v52:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9911097] Update Tracker - [Reaction:548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA - v89:[addInput]
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