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Details on Person ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

Class:Id	Reaction:548800
_displayName	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA
_doRelease	TRUE
_timestamp	2024-04-12 19:41:40
authored	[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
catalystActivity	[CatalystActivity:548806] fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643484] fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane] Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:548837] D'Eustachio, P, 2010-03-14
edited	[InstanceEdit:699799] D'Eustachio, P, 2010-05-08
input	[SimpleEntity:548819] AA-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9907566] D'Eustachio, Peter, 2024-04-12
isChimeric	FALSE
literatureReference	[LiteratureReference:2046013] Identification and expression of mammalian long-chain PUFA elongation enzymes [LiteratureReference:1660633] ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
modified	[InstanceEdit:548844] D'Eustachio, P, 2010-03-14 [InstanceEdit:548845] D'Eustachio, P, 2010-03-14 [InstanceEdit:827349] Matthews, L, 2010-05-27 [InstanceEdit:5676204] Jassal, Bijay, 2015-02-19 [InstanceEdit:5678221] D'Eustachio, Peter, 2015-02-21 [InstanceEdit:5678251] Jassal, Bijay, 2015-02-23 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20 [InstanceEdit:9907565] D'Eustachio, Peter, 2024-04-12 [InstanceEdit:9907580] D'Eustachio, Peter, 2024-04-12
name	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH
output	[SimpleEntity:548816] 3ODCT-CoA [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:548843] ACSL3,4 ligate CoA to AA to form AA-CoA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-06-15
reviewed	[InstanceEdit:5678222] D'Eustachio, Peter, 2015-02-21 [InstanceEdit:9907581] Hill, David P, 2024-04-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5676160] Jassal, Bijay, 2015-02-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105967] R-HSA-548800.4
structureModified	[InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
summation	[Summation:548798] Elongation of very long chain fatty acids proteins 1, 2, 3 a...
(hasEvent)	[Pathway:75876] Synthesis of very long-chain fatty acyl-CoAs [Homo sapiens]
(replacementInstances)	[_Deleted:5676217] Deletion of instance: 548805 [_Deleted:5676220] Deletion of instance: 548825
(updatedInstance)	[_UpdateTracker:9784559] Update Tracker - [Reaction:548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - v53:[modifyText] [_UpdateTracker:9785282] Update Tracker - [Reaction:548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - v52:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9911022] Update Tracker - [Reaction:548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - v89:[addInput]
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