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Details on Person Diagram of Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Defective gamma-carboxylation of F9, and Defective F8 sulfation at Y1699

Class:IdPathwayDiagram:548647
_displayNameDiagram of Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Defective gamma-carboxylation of F9, and Defective F8 sulfation at Y1699
_timestamp2025-06-23 15:00:10
created[InstanceEdit:548646] Gillespie, ME, 2010-03-10
height1736
modified[InstanceEdit:549008] Gillespie, ME, 2010-03-15
[InstanceEdit:597587] D'Eustachio, P, 2010-04-13
[InstanceEdit:597588] D'Eustachio, P, 2010-04-13
[InstanceEdit:631652] D'Eustachio, P, 2010-04-29
[InstanceEdit:674690] D'Eustachio, P, 2010-05-04
[InstanceEdit:773426] Matthews, L, 2010-05-21
[InstanceEdit:800633] D'Eustachio, P, 2010-05-25
[InstanceEdit:800634] D'Eustachio, P, 2010-05-25
[InstanceEdit:1663157] Jassal, B, 2011-10-14
[InstanceEdit:1664902] Jassal, B, 2011-10-14
[InstanceEdit:1665446] Jassal, B, 2011-10-14
[InstanceEdit:2262761] Matthews, L, 2012-05-20
[InstanceEdit:3149591] Jupe, S, 2013-02-18
[InstanceEdit:3159315] Jupe, S, 2013-02-20
[InstanceEdit:5358694] D'Eustachio, Peter, 2014-03-31
[InstanceEdit:5358696] D'Eustachio, Peter, 2014-03-31
[InstanceEdit:5358697] D'Eustachio, Peter, 2014-03-31
[InstanceEdit:5367032] D'Eustachio, Peter, 2014-04-25
[InstanceEdit:5444535] D'Eustachio, Peter, 2014-05-14
[InstanceEdit:5643727] D'Eustachio, Peter, 2014-11-17
[InstanceEdit:6793948] Jassal, Bijay, 2015-09-04
[InstanceEdit:6793950] Jassal, Bijay, 2015-09-04
[InstanceEdit:6806430] D'Eustachio, Peter, 2015-10-22
[InstanceEdit:6806839] D'Eustachio, Peter, 2015-10-26
[InstanceEdit:6806840] D'Eustachio, Peter, 2015-10-26
[InstanceEdit:6807226] D'Eustachio, Peter, 2015-10-29
[InstanceEdit:6807236] Jassal, Bijay, 2015-10-30
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8942449] D'Eustachio, Peter, 2016-10-14
[InstanceEdit:8942536] D'Eustachio, Peter, 2016-10-17
[InstanceEdit:9604443] Jassal, Bijay, 2018-04-03
[InstanceEdit:9629621] D'Eustachio, Peter, 2018-11-21
[InstanceEdit:9629900] D'Eustachio, Peter, 2018-11-24
[InstanceEdit:9630041] D'Eustachio, Peter, 2018-11-27
[InstanceEdit:9630801] D'Eustachio, Peter, 2018-12-03
[InstanceEdit:9631011] D'Eustachio, Peter, 2018-12-03
[InstanceEdit:9631388] D'Eustachio, Peter, 2018-12-06
[InstanceEdit:9637984] Matthews, Lisa, 2019-02-22
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9673279] Shamovsky, Veronica, 2020-01-07
[InstanceEdit:9674526] Shamovsky, Veronica, 2020-01-14
[InstanceEdit:9674527] Shamovsky, Veronica, 2020-01-14
[InstanceEdit:9687792] May, Bruce, 2020-05-12
[InstanceEdit:9793464] D'Eustachio, Peter, 2022-06-15
[InstanceEdit:9839950] D'Eustachio, Peter, 2023-07-12
[InstanceEdit:9840192] D'Eustachio, Peter, 2023-07-13
[InstanceEdit:9851915] Stephan, Ralf, 2023-11-02
[InstanceEdit:9856156] D'Eustachio, Peter, 2023-12-12
[InstanceEdit:9856200] D'Eustachio, Peter, 2023-12-13
[InstanceEdit:9958579] D'Eustachio, Peter, 2025-06-23
representedPathway[Pathway:163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation [Homo sapiens]
[Pathway:9673240] Defective gamma-carboxylation of F9 [Homo sapiens]
[Pathway:9674519] Defective F8 sulfation at Y1699 [Homo sapiens]
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id="846" stoichiometry="11" points="414 457" /> </Inputs> <Outputs> <Output id="19" points="711 397" /> <Output id="834" stoichiometry="11" points="698 352" /> <Output id="860" stoichiometry="11" points="700 457" /> </Outputs> <Catalysts> <Catalyst id="12" points="141 408, 231 335, 569 335" /> </Catalysts> <Properties> <displayName>GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="30" reactomeId="159826" points="456 549, 574 550, 636 552" position="574 550" lineWidth="1.0"> <Inputs> <Input id="31" points="310 549" /> <Input id="35" stoichiometry="10" points="273 481" /> <Input id="846" stoichiometry="10" points="418 493" /> <Input id="27" stoichiometry="10" points="360 488" /> </Inputs> <Outputs> <Output id="32" points="711 553" /> <Output id="33" stoichiometry="10" points="696 608" /> <Output id="860" stoichiometry="10" points="697 493" /> </Outputs> <Catalysts> <Catalyst id="12" points="126 448, 188 627, 575 627" /> </Catalysts> <Properties> <displayName>GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="37" reactomeId="159795" points="469 700, 580 702, 647 702" position="580 702" lineWidth="1.0"> <Inputs> <Input id="833" stoichiometry="8" points="424 742" /> <Input id="38" points="319 699" /> <Input id="49" stoichiometry="8" points="273 755" /> <Input id="48" stoichiometry="8" points="358 750" /> </Inputs> <Outputs> <Output id="39" points="706 700" /> <Output id="33" stoichiometry="8" points="699 644" /> <Output id="862" stoichiometry="8" points="695 742" /> </Outputs> <Catalysts> <Catalyst id="12" points="126 448, 184 638, 579 638" /> </Catalysts> <Properties> <displayName>GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="51" reactomeId="159752" points="463 816, 576 814, 644 815" position="576 814" lineWidth="1.0"> <Inputs> <Input id="52" points="312 817" /> <Input id="833" stoichiometry="11" points="423 778" /> <Input id="49" stoichiometry="11" points="273 764" /> <Input id="48" stoichiometry="11" points="358 770" /> </Inputs> <Outputs> <Output id="840" stoichiometry="11" points="700 887" /> <Output id="53" points="696 813" /> <Output id="862" stoichiometry="11" points="693 778" /> </Outputs> <Catalysts> <Catalyst id="12" points="124 448, 205 900, 576 897" /> </Catalysts> <Properties> <displayName>GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="57" reactomeId="163820" points="456 972, 575 972, 641 974" position="575 972" lineWidth="1.0"> <Inputs> <Input id="58" points="310 972" /> <Input id="8" stoichiometry="13" points="358 1026" /> <Input id="857" stoichiometry="13" points="420 1019" /> <Input id="69" stoichiometry="13" points="273 1031" /> </Inputs> <Outputs> <Output id="60" points="702 975" /> <Output id="835" stoichiometry="13" points="695 1019" /> <Output id="840" stoichiometry="13" points="696 923" /> </Outputs> <Catalysts> <Catalyst id="12" points="123 448, 195 906, 573 905" /> </Catalysts> <Properties> <displayName>GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="70" reactomeId="163810" points="455 1105, 575 1105, 644 1105" position="575 1105" lineWidth="1.0"> <Inputs> <Input id="71" points="312 1103" /> <Input id="857" stoichiometry="11" points="419 1055" /> <Input id="69" stoichiometry="11" points="273 1042" /> <Input id="8" stoichiometry="11" points="358 1050" /> </Inputs> <Outputs> <Output id="72" points="712 1105" /> <Output id="835" stoichiometry="11" points="697 1055" /> <Output id="73" stoichiometry="11" points="697 1155" /> </Outputs> <Catalysts> <Catalyst id="12" points="122 448, 179 1169, 574 1168" /> </Catalysts> <Properties> <displayName>GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="77" reactomeId="159836" points="818 142, 888 141, 952 141" position="888 141" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="10" /> </Inputs> <Outputs> <Output id="78" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="79" reactomeId="159783" points="819 269, 888 269, 949 268" position="888 269" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="80" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="81" reactomeId="159757" points="816 398, 888 398, 954 398" position="888 398" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="82" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="83" reactomeId="159843" points="815 541, 888 521, 952 505" position="888 521" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="32" /> </Inputs> <Outputs> <Output id="84" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="85" reactomeId="159762" points="820 706, 888 715, 949 721" position="888 715" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="39" /> </Inputs> <Outputs> <Output id="86" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="87" reactomeId="159729" points="826 812, 886 812, 945 812" position="886 812" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="53" /> </Inputs> <Outputs> <Output id="88" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="163825" points="824 976, 888 976, 949 976" position="888 976" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="90" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="91" reactomeId="163809" points="814 1106, 888 1106, 962 1106" position="888 1106" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="72" /> </Inputs> <Outputs> <Output id="92" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="94" reactomeId="159796" points="1061 157, 1455 289, 1476 297" position="1455 289" lineWidth="1.0"> <Inputs> <Input id="78" /> </Inputs> <Outputs> <Output id="95" points="1515 296" /> <Output id="96" points="1506 333" /> </Outputs> <Catalysts> <Catalyst id="97" points="1345 587" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-factor IX to factor IX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="98" reactomeId="159868" points="1056 286, 1233 333, 1283 349" position="1233 333" lineWidth="1.0"> <Inputs> <Input id="80" /> </Inputs> <Outputs> <Output id="99" points="1312 331" /> <Output id="100" points="1318 410" /> </Outputs> <Catalysts> <Catalyst id="97" points="1336 587" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-factor VII to factor VII</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="101" reactomeId="159733" points="1023 412, 1077 443, 1112 440" position="1077 443" lineWidth="1.0"> <Inputs> <Input id="82" /> </Inputs> <Outputs> <Output id="102" points="1141 440" /> <Output id="103" points="1127 391" /> </Outputs> <Catalysts> <Catalyst id="97" points="1322 587" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-factor X to factor X</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="105" reactomeId="159728" points="1061 506, 1120 522, 1120 566" position="1120 522" lineWidth="1.0"> <Inputs> <Input id="84" /> </Inputs> <Outputs> <Output id="106" points="1077 575" /> <Output id="107" points="1155 597" /> </Outputs> <Catalysts> <Catalyst id="97" points="1315 592" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-prothrombin to prothrombin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="108" reactomeId="159771" points="1063 728, 1126 730, 1127 694" position="1126 730" lineWidth="1.0"> <Inputs> <Input id="86" /> </Inputs> <Outputs> <Output id="109" points="1139 683" /> <Output id="110" points="1068 681" /> </Outputs> <Catalysts> <Catalyst id="97" points="1322 615" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-protein C to protein C</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="111" reactomeId="159773" points="1063 816, 1138 822, 1138 854" position="1138 822" lineWidth="1.0"> <Inputs> <Input id="88" /> </Inputs> <Outputs> <Output id="112" points="1101 881" /> <Output id="113" points="1159 866" /> </Outputs> <Catalysts> <Catalyst id="97" points="1330 615" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-protein S to protein S</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="114" reactomeId="163798" points="1064 972, 1231 960, 1260 959" position="1231 960" lineWidth="1.0"> <Inputs> <Input id="90" /> </Inputs> <Outputs> <Output id="115" points="1309 898" /> <Output id="116" points="1292 959" /> </Outputs> <Catalysts> <Catalyst id="97" points="1337 615" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-protein Z to protein Z</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="117" reactomeId="163843" points="1051 1094, 1423 993, 1485 975" position="1423 993" lineWidth="1.0"> <Inputs> <Input id="92" /> </Inputs> <Outputs> <Output id="118" points="1502 926" /> <Output id="119" points="1542 976" /> </Outputs> <Catalysts> <Catalyst id="97" points="1343 615" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-GAS6 to GAS6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="140" reactomeId="204647" points="1341 1501, 1362 1502, 1403 1503" position="1362 1502" lineWidth="1.0"> <Inputs> <Input id="277" points="1264 1489" /> <Input id="141" points="1288 1459" /> <Input id="142" points="1298 1526" /> </Inputs> <Outputs> <Output id="144" points="1458 1550" /> <Output id="146" points="1436 1457" /> <Output id="278" points="1478 1491" /> <Output id="145" points="1472 1523" /> </Outputs> <Catalysts> <Catalyst id="148" points="1371 1538" /> </Catalysts> <Properties> <displayName>DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="149" reactomeId="204662" points="1623 1491, 1666 1491, 1700 1491" position="1666 1491" lineWidth="1.0"> <Inputs> <Input id="278" points="1571 1488" /> <Input id="150" points="1612 1471" /> <Input id="1047" points="1595 1550" /> <Input id="1049" points="1579 1518" /> </Inputs> <Outputs> <Output id="1043" points="1738 1546" /> <Output id="280" points="1753 1488" /> <Output id="1045" points="1770 1523" /> </Outputs> <Catalysts> <Catalyst id="152" points="1666 1528" /> </Catalysts> <Properties> <displayName>DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="204617" points="1429 1480, 1388 1476, 1354 1476" position="1388 1476" lineWidth="1.0"> <Inputs> <Input id="146" points="1441 1457" /> <Input id="278" points="1478 1483" /> <Input id="144" points="1467 1550" /> <Input id="145" points="1472 1514" /> </Inputs> <Outputs> <Output id="277" points="1264 1484" /> <Output id="141" points="1301 1451" /> <Output id="142" points="1287 1523" /> </Outputs> <Catalysts> <Catalyst id="148" points="1378 1538" /> </Catalysts> <Properties> <displayName>DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="169" reactomeId="1614362" points="579 1540, 614 1541, 679 1541" position="614 1541" lineWidth="1.0"> <Inputs> <Input id="171" points="521 1537" /> <Input id="275" points="523 1508" /> </Inputs> <Outputs> <Output id="172" points="724 1541" /> <Output id="276" points="718 1500" /> <Output id="1183" points="681 1501" /> <Output id="272" points="763 1506" /> </Outputs> <Catalysts> <Catalyst id="174" points="596 1493" /> </Catalysts> <Inhibitors> <Inhibitor id="182" points="685 1446, 654 1465" /> </Inhibitors> <Properties> <displayName>SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="281" reactomeId="5358494" points="1796 786, 1796 817, 1796 842" position="1796 817" lineWidth="1.0"> <Inputs> <Input id="282" points="1796 755" /> <Input id="283" points="1759 780" /> </Inputs> <Outputs> <Output id="284" points="1796 887" /> <Output id="285" points="1754 851" /> </Outputs> <Catalysts> <Catalyst id="286" points="1835 816" /> </Catalysts> <Activators> <Activator id="287" points="1862 779" /> </Activators> <Properties> <displayName>DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="288" reactomeId="5358484" points="1796 957, 1796 986, 1796 1011" position="1796 986" lineWidth="1.0"> <Inputs> <Input id="283" stoichiometry="4" points="1716 794, 1688 839, 1688 936" /> <Input id="284" points="1796 929" /> </Inputs> <Outputs> <Output id="290" stoichiometry="4" points="1759 1017" /> <Output id="303" points="1796 1048" /> </Outputs> <Catalysts> <Catalyst id="291" points="1850 986" /> </Catalysts> <Properties> <displayName>DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="293" reactomeId="5358475" points="1796 1219, 1796 1241, 1796 1273" position="1796 1241" lineWidth="1.0"> <Inputs> <Input id="294" points="1748 1231" /> <Input id="289" points="1796 1192" /> <Input id="295" points="1755 1208" /> </Inputs> <Outputs> <Output id="296" points="1796 1310" /> <Output id="297" points="1835 1306" /> <Output id="298" points="1840 1278" /> </Outputs> <Catalysts> <Catalyst id="299" points="1850 1241" /> </Catalysts> <Properties> <displayName>DPH6 ligates ammonium to diphthine-EEF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="304" reactomeId="5367022" points="1796 1087, 1796 1114, 1796 1154" position="1796 1114" lineWidth="1.0"> <Inputs> <Input id="303" /> </Inputs> <Outputs> <Output id="289" /> </Outputs> <Catalysts> <Catalyst id="300" points="1850 1114" /> </Catalysts> <Properties> <displayName>DPH7 hydrolyzes a methyl group on Me-diphthine EEF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="306" reactomeId="6788650" points="794 1634, 843 1634, 873 1634" position="843 1634" lineWidth="1.0"> <Inputs> <Input id="307" points="727 1634" /> <Input id="311" points="743 1671" /> </Inputs> <Outputs> <Output id="308" points="939 1634" /> <Output id="313" points="917 1658" /> </Outputs> <Catalysts> <Catalyst id="309" points="843 1603" /> </Catalysts> <Properties> <displayName>ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="819" reactomeId="6788867" points="1299 1676, 1335 1676, 1375 1677" position="1335 1676" lineWidth="1.0"> <Inputs> <Input id="820" points="1277 1660" /> <Input id="821" points="1270 1676" /> </Inputs> <Outputs> <Output id="822" points="1414 1676" /> <Output id="823" points="1399 1648" /> </Outputs> <Catalysts> <Catalyst id="824" points="1334 1642" /> </Catalysts> <Properties> <displayName>FN3K phosphorylates ketosamines</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="825" reactomeId="6788855" points="1653 1663, 1707 1663, 1760 1663" position="1707 1663" lineWidth="1.0"> <Inputs> <Input id="826" points="1634 1640" /> <Input id="827" points="1634 1671" /> </Inputs> <Outputs> <Output id="829" points="1788 1670" /> <Output id="831" points="1780 1640" /> </Outputs> <Catalysts> <Catalyst id="832" points="1707 1637" /> </Catalysts> <Properties> <displayName>FN3KRP phosphorylates PsiAm, RibAm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="979" reactomeId="6807214" points="436 1209, 576 1209, 645 1210" position="576 1209" lineWidth="1.0"> <Inputs> <Input id="980" points="300 1211" /> <Input id="984" stoichiometry="3" points="276 1258" /> <Input id="986" stoichiometry="3" points="361 1251" /> <Input id="988" stoichiometry="3" points="425 1246" /> </Inputs> <Outputs> <Output id="981" points="702 1212" /> <Output id="990" stoichiometry="3" points="694 1246" /> <Output id="73" stoichiometry="3" points="687 1185" /> </Outputs> <Catalysts> <Catalyst id="12" points="121 448, 146 1181, 576 1179" /> </Catalysts> <Properties> <displayName>GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="995" reactomeId="6807229" points="825 1214, 888 1214, 948 1214" position="888 1214" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="981" /> </Inputs> <Outputs> <Output id="996" /> </Outputs> <Properties> <displayName>Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1014" reactomeId="6807224" points="1061 1199, 1477 1074, 1502 1067" position="1477 1074" lineWidth="1.0"> <Inputs> <Input id="996" /> </Inputs> <Outputs> <Output id="1015" points="1524 1064" /> <Output id="1016" points="1532 1113" /> </Outputs> <Catalysts> <Catalyst id="97" points="1344 615" /> </Catalysts> <Properties> <displayName>Furin cleaves pro-BGLAP to BGLAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1018" interactionType="Activate" points="662 206, 603 207" position="632 206" lineWidth="2.0"> <Inputs> <Input id="844" /> </Inputs> <Outputs> <Output id="1017" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1019" interactionType="Activate" points="483 207, 434 206" position="458 206" lineWidth="2.0"> <Inputs> <Input id="1017" /> </Inputs> <Outputs> <Output id="853" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1021" interactionType="Activate" points="662 474, 614 473" position="638 473" lineWidth="2.0"> <Inputs> <Input id="860" /> </Inputs> <Outputs> <Output id="1020" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1022" interactionType="Activate" points="494 473, 434 474" position="464 473" lineWidth="2.0"> <Inputs> <Input id="1020" /> </Inputs> <Outputs> <Output id="846" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1026" interactionType="Activate" points="662 760, 618 760" position="640 760" lineWidth="2.0"> <Inputs> <Input id="862" /> </Inputs> <Outputs> <Output id="1025" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1027" interactionType="Activate" points="498 760, 434 760" position="466 760" lineWidth="2.0"> <Inputs> <Input id="1025" /> </Inputs> <Outputs> <Output id="833" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1030" interactionType="Activate" points="662 1038, 621 1039" position="641 1038" lineWidth="2.0"> <Inputs> <Input id="835" /> </Inputs> <Outputs> <Output id="1029" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1031" interactionType="Activate" points="501 1039, 435 1037" position="468 1038" lineWidth="2.0"> <Inputs> <Input id="1029" /> </Inputs> <Outputs> <Output id="857" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1034" interactionType="Activate" points="664 1264, 618 1265" position="641 1264" lineWidth="2.0"> <Inputs> <Input id="990" /> </Inputs> <Outputs> <Output id="1033" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1042" interactionType="Activate" points="498 1265, 447 1264" position="472 1264" lineWidth="2.0"> <Inputs> <Input id="1033" /> </Inputs> <Outputs> <Output id="988" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1050" reactomeId="9629591" points="1760 612, 1761 559, 1759 514" position="1761 559" lineWidth="1.0"> <Inputs> <Input id="1051" points="1760 665" /> <Input id="1052" points="1804 630" /> <Input id="1058" points="1802 601" /> </Inputs> <Outputs> <Output id="1053" points="1759 447" /> <Output id="1054" points="1806 481" /> <Output id="1055" points="1799 509" /> </Outputs> <Catalysts> <Catalyst id="1056" points="1793 556" /> </Catalysts> <Properties> <displayName>JMJD7 dimer hydroxlates a lysine residue of DRG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1059" reactomeId="9629578" points="1901 612, 1902 557, 1902 517" position="1902 557" lineWidth="1.0"> <Inputs> <Input id="1060" points="1900 663" /> <Input id="1052" points="1848 631" /> <Input id="1058" points="1851 601" /> </Inputs> <Outputs> <Output id="1054" points="1847 481" /> <Output id="1055" points="1853 510" /> <Output id="1061" points="1900 447" /> </Outputs> <Catalysts> <Catalyst id="1056" points="1860 555" /> </Catalysts> <Properties> <displayName>JMJD7 dimer hydroxlates a lysine residue of DRG2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1070" reactomeId="9629888" points="1762 262, 1761 226, 1760 190" position="1761 226" lineWidth="1.0"> <Inputs> <Input id="1071" points="1760 316" /> <Input id="1082" points="1801 277" /> <Input id="1084" points="1810 311" /> </Inputs> <Outputs> <Output id="1072" points="1760 115" /> <Output id="1078" points="1808 151" /> <Output id="1080" points="1802 180" /> </Outputs> <Catalysts> <Catalyst id="1085" points="1791 226" /> </Catalysts> <Properties> <displayName>KDM8:Fe2+ hydroxylates an arginine residue of RCCD1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1086" reactomeId="9629869" points="1900 260, 1900 228, 1899 181" position="1900 228" lineWidth="1.0"> <Inputs> <Input id="1087" points="1900 321" /> <Input id="1084" points="1841 311" /> <Input id="1082" points="1850 278" /> </Inputs> <Outputs> <Output id="1088" points="1899 116" /> <Output id="1078" points="1848 151" /> <Output id="1080" points="1856 177" /> </Outputs> <Catalysts> <Catalyst id="1085" points="1860 227" /> </Catalysts> <Properties> <displayName>KDM8:Fe2+ hydroxylates an arginine residue of RPS6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1098" reactomeId="9629946" points="2099 627, 2099 596, 2099 564" position="2099 596" lineWidth="1.0"> <Inputs> <Input id="1099" points="2099 656" /> <Input id="1107" points="2060 649" /> <Input id="1109" points="2063 619" /> </Inputs> <Outputs> <Output id="1100" points="2099 518" /> <Output id="1103" points="2068 545" /> <Output id="1105" points="2065 568" /> </Outputs> <Catalysts> <Catalyst id="1101" points="2129 593" /> </Catalysts> <Properties> <displayName>JMJD4:Fe2+ hydroxylates a lysine residue of ETF1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1114" reactomeId="9630022" points="2091 299, 2091 260, 2089 220" position="2091 260" lineWidth="1.0"> <Inputs> <Input id="1116" points="2091 354" /> <Input id="1129" stoichiometry="2" points="2143 304" /> <Input id="1127" stoichiometry="2" points="2142 333" /> </Inputs> <Outputs> <Output id="1118" points="2089 152" /> <Output id="1131" stoichiometry="2" points="2137 194" /> <Output id="1133" stoichiometry="2" points="2139 218" /> </Outputs> <Catalysts> <Catalyst id="1121" points="2055 261" /> </Catalysts> <Properties> <displayName>JMJD6 dimer hydroxylates lysine residues of U2AF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1122" reactomeId="9630769" points="2228 300, 2228 262, 2226 224" position="2228 262" lineWidth="1.0"> <Inputs> <Input id="1123" points="2226 354" /> <Input id="1127" points="2182 333" /> <Input id="1129" points="2183 304" /> </Inputs> <Outputs> <Output id="1124" points="2226 153" /> <Output id="1131" points="2182 194" /> <Output id="1133" points="2188 220" /> </Outputs> <Catalysts> <Catalyst id="1134" points="2260 262" /> </Catalysts> <Properties> <displayName>OGFOD1:Fe2+ hydroxylates a proline residue of RPS23</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1135" reactomeId="9630993" points="2445 301, 2444 262, 2443 220" position="2444 262" lineWidth="1.0"> <Inputs> <Input id="1117" points="2481 325" /> <Input id="1136" points="2445 354" /> <Input id="1115" points="2481 296" /> </Inputs> <Outputs> <Output id="1137" points="2442 153" /> <Output id="1119" points="2477 218" /> <Output id="1120" points="2479 197" /> </Outputs> <Catalysts> <Catalyst id="1138" points="2412 262" /> </Catalysts> <Properties> <displayName>RIOX1:Fe2+ hydroxylates a histidine residue of RPL8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1140" reactomeId="9630967" points="2563 299, 2562 265, 2560 221" position="2562 265" lineWidth="1.0"> <Inputs> <Input id="1117" points="2522 325" /> <Input id="1115" points="2521 295" /> <Input id="1141" points="2563 354" /> </Inputs> <Outputs> <Output id="1119" points="2526 219" /> <Output id="1120" points="2522 197" /> <Output id="1142" points="2556 155" /> </Outputs> <Catalysts> <Catalyst id="1143" points="2602 264" /> </Catalysts> <Properties> <displayName>RIOX2Fe2+ hydroxylates a histidine residue of RPL27A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1144" reactomeId="9631355" points="236 1382, 282 1382, 328 1382" position="282 1382" lineWidth="1.0"> <Inputs> <Input id="1145" points="216 1382" /> <Input id="1146" points="209 1404" /> <Input id="1150" points="234 1439" /> </Inputs> <Outputs> <Output id="1147" points="359 1404" /> <Output id="1152" points="397 1383" /> <Output id="1154" points="332 1440" /> </Outputs> <Catalysts> <Catalyst id="1148" points="280 1341" /> </Catalysts> <Properties> <displayName>ASPH:Fe2+ hydroxylates an aspartate residue of F9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1177" reactomeId="9668023" points="1178 1286, 1205 1285, 1227 1286" position="1205 1285" lineWidth="1.0"> <Inputs> <Input id="1178" stoichiometry="2" points="1166 1271" /> <Input id="1179" points="1147 1286" /> </Inputs> <Outputs> <Output id="1180" stoichiometry="2" points="1238 1268" /> <Output id="1181" points="1275 1286" /> </Outputs> <Catalysts> <Catalyst id="1182" points="1205 1316" /> </Catalysts> <Properties> <displayName>TPST1,2 transfer SO4(2-) from PAPS to FVIII</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1184" reactomeId="1614336" points="614 1430, 653 1430, 685 1430" position="653 1430" lineWidth="1.0"> <Inputs> <Input id="181" points="585 1430" /> <Input id="174" points="597 1465" /> </Inputs> <Outputs> <Output id="182" /> </Outputs> <Catalysts> <Catalyst id="181" points="585 1420, 650 1400" /> </Catalysts> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Defective gamma-carboxylation of F9, and Defective F8 sulfation at Y1699 (548647)
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