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Details on Person UniProt:P02675 FGB
| Class:Id | ReferenceGeneProduct:54842 |
|---|---|
| _chainChangeLog | signal peptide:1-30 added on Fri February 6 2015;peptide:31-44 added on Fri February 6 2015;chain:45-491 added on Fri February 6 2015 |
| _displayName | UniProt:P02675 FGB |
| _timestamp | 2024-11-03 19:56:12 |
| chain | signal peptide:1-30 peptide:31-44 chain:45-491 |
| checksum | B92FFB9976AB53C5 |
| comment | FUNCTION Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.SUBUNIT Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.INTERACTION Detected in blood plasma (at protein level).DOMAIN A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.PTM Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.DISEASE The disease is caused by variants affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.ONLINE INFORMATION Fibrinogen entry |
| description | recommendedName: Fibrinogen beta chain component recommendedName: Fibrinopeptide B /component component recommendedName: Fibrinogen beta chain /component |
| geneName | FGB |
| identifier | P02675 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Blood coagulation Coiled coil Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Immunity Innate immunity Proteomics identification Pyrrolidone carboxylic acid Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FGB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988394] ENSEMBL:ENSG00000171564 FGB [Homo sapiens] |
| secondaryIdentifier | FIBB_HUMAN A0JLR9 B2R7G3 Q32Q65 Q3KPF2 |
| sequenceLength | 491 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:140584] FGB [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140846] FGB(31-491) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140876] FGB(31-44) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140917] FGB [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:140921] FGB(31-491) [platelet alpha granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P02675 FGB (54842)
