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Details on Person Hh processing variants are ubiquitinated

Class:Id	Reaction:5483238
_displayName	Hh processing variants are ubiquitinated
_doRelease	TRUE
_timestamp	2018-11-28 18:32:09
authored	[InstanceEdit:5483111] Rothfels, Karen, 2014-05-16
catalystActivity	[CatalystActivity:5483235] ubiquitin-protein transferase activity of SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:5483240] Rothfels, Karen, 2014-05-16
disease	[Disease:5358398] holoprosencephaly
edited	[InstanceEdit:5490367] D'Eustachio, Peter, 2014-05-19
entityFunctionalStatus	[EntityFunctionalStatus:9630074] gain_of_function of SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
input	[Complex:5387378] SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
modified	[InstanceEdit:5492214] Rothfels, Karen, 2014-05-20 [InstanceEdit:9630082] Rothfels, Karen, 2018-11-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh processing variants are ubiquitinated
output	[Complex:5483239] ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:5387386] Hh processing variants are recruited to SEL1:SYVN at the ER membrane [Homo sapiens] [Reaction:5362450] Hh processing variants bind lectins [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644931] R-HSA-5483238.3
summation	[Summation:5483236] Processing-defective SHH variants are ubiquitinated by SYVN1...
(hasEvent)	[Pathway:5362768] Hh mutants are degraded by ERAD [Homo sapiens]
(precedingEvent)	[Reaction:5387389] Hh processing variants are translocated to the cytosol in a VCP-dependent manner [Homo sapiens]
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No pathways have been reviewed or authored by Hh processing variants are ubiquitinated (5483238)