Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9Y613 FHOD1
| Class:Id | ReferenceGeneProduct:54828 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-1164 added on Fri February 6 2015;initiator methionine:1 for 54828 removed on Fri Nov 03 2023;initiator methionine: for 54828 added on Fri Nov 03 2023;initiator methionine: for 54828 removed on Fri Aug 15 2025;initiator methionine:1 for 54828 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9Y613 FHOD1 |
| _timestamp | 2026-02-20 23:05:30 |
| chain | initiator methionine:1 chain:2-1164 |
| checksum | E6C7AE1FB8DC3FC7 |
| comment | FUNCTION Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.SUBUNIT Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus. Interacts with ROCK1 in a Src-dependent manner.SUBCELLULAR LOCATION Predominantly cytoplasmic.TISSUE SPECIFICITY Ubiquitous. Highly expressed in spleen.DOMAIN The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.PTM Phosphorylated by ROCK1.SIMILARITY Belongs to the formin homology family. |
| description | recommendedName: FH1/FH2 domain-containing protein 1 alternativeName: Formin homolog overexpressed in spleen 1 shortName: FHOS alternativeName: Formin homology 2 domain-containing protein 1 |
| geneName | FHOD1 FHOS FHOS1 |
| identifier | Q9Y613 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Actin-binding Cell projection Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | FHOD1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988951] ENSEMBL:ENSG00000135723 FHOD1 [Homo sapiens] |
| secondaryIdentifier | FHOD1_HUMAN Q59F76 Q6Y1F2 Q76MS8 Q8N521 |
| sequenceLength | 1164 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201613] FHOD1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:517890] FHOD1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:517904] FHOD1 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y613 FHOD1 (54828)
