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Details on Person UniProt:Q9NSA1 FGF21
| Class:Id | ReferenceGeneProduct:54804 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Fri February 6 2015;chain:29-209 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NSA1 FGF21 |
| _timestamp | 2024-11-03 19:45:46 |
| chain | signal peptide:1-28 chain:29-209 |
| checksum | 27925C52A0023823 |
| comment | FUNCTION Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.SUBUNIT Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4.INTERACTION Belongs to the heparin-binding growth factors family. |
| description | recommendedName: Fibroblast growth factor 21 shortName: FGF-21 |
| geneName | FGF21 UNQ3115/PRO10196 |
| identifier | Q9NSA1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Growth factor Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FGF21 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6784674] ENSEMBL:ENSG00000105550 FGF21 [Homo sapiens] |
| secondaryIdentifier | FGF21_HUMAN Q8N683 |
| sequenceLength | 209 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:189909] FGF21 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6784692] FGF21 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NSA1 FGF21 (54804)
