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Details on Person UniProt:P31994 FCGR2B
| Class:Id | ReferenceGeneProduct:54722 |
|---|---|
| _chainChangeLog | signal peptide:1-42 added on Fri February 6 2015;chain:43-310 added on Fri February 6 2015 |
| _displayName | UniProt:P31994 FCGR2B |
| _timestamp | 2026-02-20 22:21:26 |
| chain | signal peptide:1-42 chain:43-310 |
| checksum | 2186F8538FF01F36 |
| comment | FUNCTION Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.SUBUNIT Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. Interacts with the Fc region of IgG1, IgG3 and IgG4 isotypes assembled in immune complexes.SUBUNIT (Microbial infection) Isoform IIB1 interacts with measles virus protein N. Protein N is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response.INTERACTION Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.DOMAIN Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.PTM Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.POLYMORPHISM FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162].DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.CAUTION Has sometimes been attributed to correspond to FcR-IIC.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Low affinity immunoglobulin gamma Fc region receptor II-b shortName: IgG Fc receptor II-b alternativeName: CDw32 alternativeName: Fc-gamma RII-b shortName: Fc-gamma-RIIb shortName: FcRII-b cdAntigenNameCD32/cdAntigenName |
| geneName | FCGR2B CD32 FCG2 IGFR2 |
| identifier | P31994 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Chromosomal rearrangement Disulfide bond Glycoprotein Host-virus interaction IgG-binding protein Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Proto-oncogene Receptor Reference proteome Repeat Signal Systemic lupus erythematosus Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | FCGR2B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989522] ENSEMBL:ENSG00000072694 FCGR2B [Homo sapiens] |
| secondaryIdentifier | FCG2B_HUMAN A6H8N3 O95649 Q53X85 Q5VXA9 Q8NIA1 |
| sequenceLength | 310 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:147250] UniProt:P31994-2 FCGR2B [Homo sapiens] [ReferenceIsoform:147251] UniProt:P31994-3 FCGR2B [Homo sapiens] [ReferenceIsoform:403659] UniProt:P31994-1 FCGR2B [Homo sapiens] [ReferenceIsoform:8975573] UniProt:P31994-4 FCGR2B [Homo sapiens] [ReferenceIsoform:8975574] UniProt:P31994-5 FCGR2B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:197854] FCGR2B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9940531] FCGR2B (follicular dendritic cell) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9946340] FCGR2B (GC B cell) [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P31994 FCGR2B (54722)
