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Details on Person UniProt:P12318 FCGR2A
| Class:Id | ReferenceGeneProduct:54720 |
|---|---|
| _chainChangeLog | signal peptide:1-33 added on Fri February 6 2015;chain:34-317 added on Fri February 6 2015 |
| _displayName | UniProt:P12318 FCGR2A |
| _timestamp | 2026-02-20 22:21:25 |
| chain | signal peptide:1-33 chain:34-317 |
| checksum | 07F73F3BB282DFF6 |
| comment | FUNCTION Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.SUBUNIT Binds the Fc region of antigen-complexed IgG1, IgG2, IgG3 and IgG4 isotypes (PubMed:11711607, PubMed:28566370, PubMed:37421619). Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.INTERACTION Found on monocytes, neutrophils and eosinophil platelets.PTM Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK. |
| description | recommendedName: Low affinity immunoglobulin gamma Fc region receptor II-a shortName: IgG Fc receptor II-a alternativeName: CDw32 alternativeName: Fc-gamma RII-a shortName: Fc-gamma-RIIa shortName: FcRII-a cdAntigenNameCD32/cdAntigenName |
| geneName | FCGR2A CD32 FCG2 FCGR2A1 IGFR2 |
| identifier | P12318 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein IgG-binding protein Immunity Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | FCGR2A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998308] ENSEMBL:ENSG00000143226 FCGR2A [Homo sapiens] |
| secondaryIdentifier | FCG2A_HUMAN Q8WUN1 Q8WW64 |
| sequenceLength | 317 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:423465] UniProt:P12318-1 FCGR2A [Homo sapiens] [ReferenceIsoform:423466] UniProt:P12318-2 FCGR2A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:197838] FCGR2A [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1861738] p-Y288,Y304-FCGR2A [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2029069] p-Y288,Y304-FCGR2A [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6804791] FCGR2A [secretory granule membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:1861626] O4'-phospho-L-tyrosine at 288 [ModifiedResidue:1861668] O4'-phospho-L-tyrosine at 304 |
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No pathways have been reviewed or authored by UniProt:P12318 FCGR2A (54720)
