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Details on Person UniProt:P06734 FCER2
| Class:Id | ReferenceGeneProduct:54710 |
|---|---|
| _chainChangeLog | chain:1-321 added on Fri February 6 2015;chain:150-321 added on Fri February 6 2015 |
| _displayName | UniProt:P06734 FCER2 |
| _timestamp | 2024-11-03 19:45:45 |
| chain | chain:1-321 chain:150-321 |
| checksum | F86708C0E6515B87 |
| comment | FUNCTION Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003).SUBUNIT Homotrimer. Interacts (via C-type lectin domain) with IGHE (via CH3 region); this interaction regulates IgE homeostasis. Interacts (via the C-terminus) with CR2/CD21 (via Sushi domain 1 and 2) (PubMed:1386409, PubMed:16172256).INTERACTION Also exists as a soluble excreted form, sCD23.TISSUE SPECIFICITY Detected in urine (at protein level).PTM N- and O-glycosylated.PTM The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.MISCELLANEOUS There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.SEQUENCE CAUTION CD23 |
| description | recommendedName: Low affinity immunoglobulin epsilon Fc receptor alternativeName: BLAST-2 alternativeName: C-type lectin domain family 4 member J alternativeName: Fc-epsilon-RII alternativeName: Immunoglobulin E-binding factor alternativeName: Lymphocyte IgE receptor cdAntigenNameCD23/cdAntigenName component recommendedName: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form /component component recommendedName: Low affinity immunoglobulin epsilon Fc receptor soluble form /component |
| geneName | FCER2 CD23A CLEC4J FCE2 IGEBF |
| identifier | P06734 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cell membrane Direct protein sequencing Disulfide bond Glycoprotein IgE-binding protein Lectin Lipoprotein Membrane Metal-binding Palmitate Proteoglycan Proteomics identification Receptor Reference proteome Repeat Secreted Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | FCER2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2127278] ENSEMBL:ENSG00000104921 FCER2 [Homo sapiens] |
| secondaryIdentifier | FCER2_HUMAN |
| sequenceLength | 321 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2127280] FCER2(1-321) [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P06734 FCER2 (54710)
