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Details on Person UniProt:P12259 F5
| Class:Id | ReferenceGeneProduct:54598 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Fri February 6 2015;chain:29-2224 added on Fri February 6 2015;chain:29-737 added on Fri February 6 2015;propeptide:738-1573 added on Fri February 6 2015;chain:1574-2224 added on Fri February 6 2015 |
| _displayName | UniProt:P12259 F5 |
| _timestamp | 2024-11-03 20:09:54 |
| chain | signal peptide:1-28 chain:29-2224 chain:29-737 propeptide:738-1573 chain:1574-2224 |
| checksum | 24AEF3FEA7332E37 |
| comment | FUNCTION Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.ACTIVITY REGULATION Inhibited by SERPINA5.SUBUNIT Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5.INTERACTION Plasma.DOMAIN Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.PTM Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).PTM Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.PTM Activated protein C inactivates factor V and factor Va by proteolytic degradation.PTM Phosphorylated by FAM20C in the extracellular medium.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the multicopper oxidase family.SEQUENCE CAUTION Factor V entry |
| description | recommendedName: Coagulation factor V alternativeName: Activated protein C cofactor alternativeName: Proaccelerin, labile factor component recommendedName: Coagulation factor V heavy chain /component component recommendedName: Coagulation factor V light chain /component |
| geneName | F5 |
| identifier | P12259 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Blood coagulation Calcium Copper Disease variant Disulfide bond Glycoprotein Hemostasis Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal Sulfation Thrombophilia Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | F5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994216] ENSEMBL:ENSG00000198734 F5 [Homo sapiens] |
| secondaryIdentifier | FA5_HUMAN A8K6E8 Q14285 Q2EHR5 Q5R346 Q5R347 Q6UPU6 Q8WWQ6 |
| sequenceLength | 2224 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:140653] factor Va heavy chain [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:140660] factor Va light chain [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:140690] factor Va light chain [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140691] factor Va heavy chain [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140697] factor V [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140787] factor V activation peptide [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:141766] factor V [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:5605101] F5(29-334) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5605102] F5(335-534) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5605103] F5(535-737) [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8956946] phosphorylated residue at unknown position [ReplacedResidue:9930407] L-arginine 534 replaced with L-glutamine [ReplacedResidue:9930430] L-isoleucine 387 replaced with L-threonine [ReplacedResidue:9930436] L-arginine 334 replaced with L-threonine [ReplacedResidue:9930480] L-alanine 540 replaced with L-valine |
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No pathways have been reviewed or authored by UniProt:P12259 F5 (54598)
