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Details on Person UniProt:P00748 F12

Class:IdReferenceGeneProduct:54586
_chainChangeLogsignal peptide:1-19 added on Fri February 6 2015;chain:20-372 added on Fri February 6 2015;chain:354-362 added on Fri February 6 2015;chain:373-615 added on Fri February 6 2015;chain:373-615 added on Fri February 6 2015
_displayNameUniProt:P00748 F12
_timestamp2025-05-21 21:18:11
chainsignal peptide:1-19
chain:20-372
chain:354-362
chain:373-615
checksumF5B861BF635EB480
commentFUNCTION Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (PubMed:2019570, PubMed:21304106, PubMed:8427954).CATALYTIC ACTIVITY Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.ACTIVITY REGULATION Activity is promoted in the presence of negatively charged surfaces.SUBUNIT Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation.(PubMed:21304106) Interacts (inactive and activated) with D7L2, an anticoagulant protein from Anopheles gambiae (PubMed:35460690). Interacts (activated) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392). Interacts (inactive and activated) (via amino acids 1-77) with triafestin-1 and triafestin-2, anticoagulant proteins from Triatoma infestans (PubMed:17645545). Interacts (inactive and activated) (via amino acids 1-77) with short form salivary protein D7R1, an anticoagulant protein from Anopheles stephensi (PubMed:17645545). Interacts (inactive and activated) (via fibronectin type II domain) with haemaphysalin, an anticoagulant protein from Haemaphysalis longicornis (PubMed:15711755, PubMed:16169873).INTERACTION Factor XII is activated by kallikrein in alpha-factor XIIa, which is further converted by trypsin into beta-factor XIIa. Alpha-factor XIIa is composed of an NH2-terminal heavy chain, called coagulation factor XIIa heavy chain, and a COOH-terminal light chain, called coagulation factor XIIa light chain, connected by a disulfide bond. Beta-factor XIIa is composed of 2 chains linked by a disulfide bond, an N-terminal nonapeptide, called beta-factor XIIa part 1, and coagulation factor XIIa light chain, also known in this context as beta-factor XIIa part 2.PTM O- and N-glycosylated. The O-linked polysaccharides were not identified, but are probably the mucin type linked to GalNAc.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1 family.ONLINE INFORMATION Factor XII entry
descriptionrecommendedName: Coagulation factor XII ecNumber evidence="20 33"3.4.21.38 alternativeName: Hageman factor shortName: HAF component recommendedName: Coagulation factor XIIa heavy chain /component component recommendedName: Beta-factor XIIa part 1 /component component recommendedName: Coagulation factor XIIa light chain alternativeName: Beta-factor XIIa part 2 /component
geneNameF12
identifierP00748
isSequenceChangedFALSE
keyword3D-structure
Blood coagulation
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Fibrinolysis
Glycoprotein
Hemostasis
Hydrolase
Kringle
Protease
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9909836] Weiser, Joel, 2024-05-14
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
nameF12
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8987819] ENSEMBL:ENSG00000131187 F12 [Homo sapiens]
secondaryIdentifierFA12_HUMAN
P78339
sequenceLength615
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:158214] factor XII [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:158285] factor XIIa heavy chain [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:158320] factor XIIa light chain [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:9653225] F12 T328R(20-328) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:9653226] F12 T328R [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9653230] F12 T328K(20-328) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:9653238] F12 T328K [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9653243] F12 T328R (329-615) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:9653252] F12 T328K (329-615) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:9655053] F12 T328K (373-615) [extracellular region] [Homo sapiens]
List all 14 refering instances
(referenceSequence)[ReplacedResidue:9653237] L-threonine 328 replaced with L-arginine
[ReplacedResidue:9653240] L-threonine 328 replaced with L-lysine
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No pathways have been reviewed or authored by UniProt:P00748 F12 (54586)
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