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Details on Person UniProt:P03951 F11

Class:Id	ReferenceGeneProduct:54584
_chainChangeLog	signal peptide:1-18 added on Sat February 7 2015;chain:19-387 added on Sat February 7 2015;chain:388-625 added on Sat February 7 2015
_displayName	UniProt:P03951 F11
_timestamp	2025-02-21 18:56:27
chain	signal peptide:1-18 chain:19-387 chain:388-625
checksum	147AFA94B7709E8F
comment	FUNCTION Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.CATALYTIC ACTIVITY Selective cleavage of Arg-\|-Ala and Arg-\|-Val bonds in factor IX to form factor IXa.ACTIVITY REGULATION Inhibited by SERPINA5.BIOPHYSICOCHEMICAL PROPERTIES kcat is 10 min(-1) for cleavage after 'Arg-191' in F9 (in the presence of 5 mM CaCl(2), from initial velocities). kcat is 7.1 min(-1) for cleavage after 'Arg-226' in F9 cleaved at 'Arg-191' (in the presence of 5 mM CaCl(2), from initial velocities). kcat is 4.6 min(-1) for cleavage after 'Arg-191' in F9 (in the absence of Ca(2+), from initial velocities). kcat is 35 min(-1) for cleavage after 'Arg-226' in F9 (in the presence of 5 mM CaCl(2), from full-progress experimental traces). kcat is 12 min(-1) for cleavage after 'Arg-226' in F9 cleaved at 'Arg-191' (in the presence of 5 mM CaCl(2), from full-progress experimental traces). kcat is 3.6 min(-1) for cleavage after 'Arg-226' in F9 (in the absence of Ca(2+), from full-progress experimental traces). kcat is 12 min(-1) for cleavage after 'Arg-191' in F9 (in the presence of 5 mM CaCl(2), from full-progress experimental traces). kcat is 6.5 min(-1) for cleavage after 'Arg-191' in F9 (in the absence of Ca(2+), from full-progress experimental traces).SUBUNIT Homodimer; disulfide-linked (PubMed:19548906, PubMed:22961984). Can form non-covalently bonded homodimers (PubMed:19548906). After activation the heavy and light chains are also linked by a disulfide bond (PubMed:22961984). Interacts (activated) with F9 (inactive and activated) in calcium-dependent manner (PubMed:22961984). Forms a heterodimer with SERPINA5 (PubMed:2844223). Interacts with Anopheles gambiae D7L2 (PubMed:35460690). Interacts (activated) with guianensin, an anticoagulant protein from Simulium guianense saliva (PubMed:37469515).INTERACTION Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.PTM N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.PTM Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. Activated by F12 (activated); the presence of negatively charged surfaces accelerates activation (PubMed:2019570, PubMed:8427954). Activated by F2 (thrombin); the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, strongly accelerates activation (PubMed:2019570, PubMed:21976677). Autoactivated; the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, accelerates autoactivation and autolysis (PubMed:2019570, PubMed:21976677).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1 family. Plasma kallikrein subfamily.ONLINE INFORMATION Factor XI entryONLINE INFORMATION Leiden Open Variation Database (LOVD)
description	recommendedName: Coagulation factor XI shortName: FXI ecNumber evidence="27"3.4.21.27 alternativeName: Plasma thromboplastin antecedent shortName: PTA component recommendedName: Coagulation factor XIa heavy chain /component component recommendedName: Coagulation factor XIa light chain /component
geneName	F11
identifier	P03951
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Heparin-binding Hydrolase Protease Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Zymogen
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	F11
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9002945] ENSEMBL:ENSG00000088926 F11 [Homo sapiens]
secondaryIdentifier	FA11_HUMAN D3DP64 Q4W5C2 Q9Y495
sequenceLength	625
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:147147] UniProt:P03951-2 F11 [Homo sapiens] [ReferenceIsoform:402355] UniProt:P03951-1 F11 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:158124] factor XIa light chain [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158208] factor XI monomer [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158260] factor XI monomer [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158263] factor XIa heavy chain [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9678402] FXI monomer [endoplasmic reticulum lumen] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P03951 F11 (54584)