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Details on Person UniProt:P16118 PFKFB1
| Class:Id | ReferenceGeneProduct:54572 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-471 added on Fri February 6 2015;initiator methionine:1 for 54572 removed on Fri Nov 03 2023;initiator methionine: for 54572 added on Fri Nov 03 2023;initiator methionine: for 54572 removed on Fri Aug 15 2025;initiator methionine:1 for 54572 added on Fri Aug 15 2025 |
| _displayName | UniProt:P16118 PFKFB1 |
| _timestamp | 2025-08-15 21:29:57 |
| chain | initiator methionine:1 chain:2-471 |
| checksum | C4FF081A295FB7D3 |
| comment | FUNCTION Synthesis and degradation of fructose 2,6-bisphosphate.CATALYTIC ACTIVITY beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphateCATALYTIC ACTIVITY beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + H(+)ACTIVITY REGULATION Phosphorylation at Ser-33 inhibits the kinase and activates the bisphosphatase.SUBUNIT Homodimer.INTERACTION Liver.SIMILARITY In the C-terminal section; belongs to the phosphoglycerate mutase family. |
| description | recommendedName: fullName evidence="8"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 shortName: 6PF-2-K/Fru-2,6-P2ase 1 shortName: PFK/FBPase 1 alternativeName: 6PF-2-K/Fru-2,6-P2ase liver isozyme domain recommendedName: 6-phosphofructo-2-kinase ecNumber evidence="2"2.7.1.105 /domain domain recommendedName: Fructose-2,6-bisphosphatase ecNumber evidence="6"3.1.3.46 /domain |
| geneName | PFKFB1 F6PK PFRX |
| identifier | P16118 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Hydrolase Kinase Multifunctional enzyme Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PFKFB1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004688] ENSEMBL:ENSG00000158571 PFKFB1 [Homo sapiens] |
| secondaryIdentifier | F261_HUMAN B2RA88 B4DUN5 Q5JXS5 Q99951 |
| sequenceLength | 471 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970484] UniProt:P16118-1 PFKFB1 [Homo sapiens] [ReferenceIsoform:8970485] UniProt:P16118-2 PFKFB1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71785] PFKFB1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:163749] p-S33-PFKFB1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:163774] O-phospho-L-serine at 33 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P16118 PFKFB1 (54572)
