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Details on Person UniProt:O60883 GPR37L1
| Class:Id | ReferenceGeneProduct:54486 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;chain:26-481 added on Fri February 6 2015 |
| _displayName | UniProt:O60883 GPR37L1 |
| _timestamp | 2024-11-03 19:41:01 |
| chain | signal peptide:1-25 chain:26-481 |
| checksum | EE9DFE0446E3AF24 |
| comment | FUNCTION G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).SUBUNIT Interacts with the PTCH1 receptor.INTERACTION Associates with the basal membrane of Bergmann glia cell primary cilia.TISSUE SPECIFICITY Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).DOMAIN The N-terminal region is required for constitutive signal transduction.PTM O-glycosylated.PTM Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.PTM Ubiquitinated.SIMILARITY Belongs to the G-protein coupled receptor 1 family.CAUTION Has been reported to act as a receptor for prosaposin (PSAP) (PubMed:23690594). However, it has also been shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor (PubMed:27072655). |
| description | recommendedName: G-protein coupled receptor 37-like 1 alternativeName: Endothelin B receptor-like protein 2 shortName: ETBR-LP-2 |
| geneName | GPR37L1 ETBRLP2 |
| identifier | O60883 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Cell projection Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GPR37L1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993021] ENSEMBL:ENSG00000170075 GPR37L1 [Homo sapiens] |
| secondaryIdentifier | G37L1_HUMAN B2R7M9 Q5SXP7 Q86VP7 |
| sequenceLength | 481 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5336178] GPR37L1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O60883 GPR37L1 (54486)
