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Details on Person UniProt:P05305 EDN1
| Class:Id | ReferenceGeneProduct:54480 |
|---|---|
| _chainChangeLog | signal peptide:1-17 added on Sat February 7 2015;propeptide:18-50 added on Sat February 7 2015;peptide:53-90 added on Sat February 7 2015;peptide:53-73 added on Sat February 7 2015;propeptide:74-212 added on Sat February 7 2015 |
| _displayName | UniProt:P05305 EDN1 |
| _timestamp | 2024-11-03 19:51:02 |
| chain | signal peptide:1-17 propeptide:18-50 peptide:53-90 peptide:53-73 propeptide:74-212 |
| checksum | E2DA0EB86755BC3D |
| comment | FUNCTION Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity).INTERACTION Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the endothelin/sarafotoxin family.ONLINE INFORMATION Endothelin entry |
| description | recommendedName: Endothelin-1 alternativeName: Preproendothelin-1 shortName: PPET1 component recommendedName: Endothelin-1 shortName: ET-1 /component component recommendedName: Big endothelin-1 /component |
| geneName | EDN1 |
| identifier | P05305 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Proteomics identification Reference proteome Secreted Signal Vasoactive Vasoconstrictor |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | EDN1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002930] ENSEMBL:ENSG00000078401 EDN1 [Homo sapiens] |
| secondaryIdentifier | EDN1_HUMAN Q96DA1 |
| sequenceLength | 212 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:388545] EDN1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8876870] EDN1(53-90) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8878413] EDN1(53-90) [transport vesicle] [Homo sapiens] [EntityWithAccessionedSequence:8878414] EDN1 [transport vesicle] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P05305 EDN1 (54480)
