Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person MLH1 S252* [nucleoplasm]

Class:IdEntityWithAccessionedSequence:5444526
_displayNameMLH1 S252* [nucleoplasm]
_timestamp2025-09-29 21:43:36
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5444519] Gillespie, Marc E, 2014-05-14
disease[Disease:4791250] colorectal cancer
endCoordinate252
hasModifiedResidue[NonsenseMutation:5444525] Nonsense mutation at L-serine 252
literatureReference[LiteratureReference:5444524] Mutation of a mutL homolog in hereditary colon cancer
modified[InstanceEdit:5545473] Gillespie, Marc E, 2014-05-21
[InstanceEdit:5575580] Gillespie, Marc E, 2014-05-24
[InstanceEdit:5577248] Gillespie, Marc E, 2014-05-30
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9646281] Rothfels, Karen, 2019-05-21
[InstanceEdit:9967511] D'Eustachio, Peter, 2025-09-29
nameMLH1 S252*
MLH1 SER252TER
DNA mismatch repair protein Mlh1
MLH1_HUMAN
referenceEntity[ReferenceGeneProduct:59369] UniProt:P40692 MLH1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8899375] R-HSA-5444526.3
startCoordinate2
(hasMember)[DefinedSet:5444521] MLH1 Variants [nucleoplasm] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9900764] Update Tracker - [EntityWithAccessionedSequence:5444526] MLH1 S252* [nucleoplasm] - v70:[addName]
[_UpdateTracker:9972188] Update Tracker - [EntityWithAccessionedSequence:5444526] MLH1 S252* [nucleoplasm] - v95:[modifyStartCoordinate]
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No pathways have been reviewed or authored by MLH1 S252* [nucleoplasm] (5444526)