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Details on Person UniProt:P53602 MVD

Class:IdReferenceGeneProduct:54404
_chainChangeLoginitiator methionine:1 added on Sat February 7 2015;chain:2-400 added on Sat February 7 2015;initiator methionine:1 for 54404 removed on Fri Nov 03 2023;initiator methionine: for 54404 added on Fri Nov 03 2023;initiator methionine: for 54404 removed on Fri Aug 15 2025;initiator methionine:1 for 54404 added on Fri Aug 15 2025
_displayNameUniProt:P53602 MVD
_timestamp2025-08-15 21:08:54
chaininitiator methionine:1
chain:2-400
checksum3FD4741BCC4B68D8
commentFUNCTION Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.CATALYTIC ACTIVITY (R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2BIOPHYSICOCHEMICAL PROPERTIES Steroid biosynthesis; cholesterol biosynthesis.SUBUNIT Homodimer.SUBCELLULAR LOCATION Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the diphosphomevalonate decarboxylase family.CAUTION Was originally thought to be located in the peroxisome (PubMed:11108725). However, was later shown to be cytosolic (PubMed:14972328).
descriptionrecommendedName: Diphosphomevalonate decarboxylase ecNumber evidence="4 6 7"4.1.1.33 alternativeName: Mevalonate (diphospho)decarboxylase shortName: MDDase alternativeName: Mevalonate pyrophosphate decarboxylase
geneNameMVD
MPD
identifierP53602
isSequenceChangedFALSE
keyword3D-structure
Acetylation
ATP-binding
Cholesterol biosynthesis
Cholesterol metabolism
Cytoplasm
Disease variant
Lipid biosynthesis
Lipid metabolism
Lyase
Nucleotide-binding
Phosphoprotein
Proteomics identification
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
nameMVD
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:2393976] ENSEMBL:ENSG00000167508 MVD [Homo sapiens]
secondaryIdentifierMVD1_HUMAN
Q53Y65
sequenceLength400
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:191317] MVD [cytosol] [Homo sapiens]
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