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Details on Person UniProt:O95925 EPPIN
| Class:Id | ReferenceGeneProduct:54398 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Fri February 6 2015;chain:22-133 added on Fri February 6 2015 |
| _displayName | UniProt:O95925 EPPIN |
| _timestamp | 2025-08-15 21:22:24 |
| chain | signal peptide:1-21 chain:22-133 |
| checksum | F7831B203366D9DC |
| comment | FUNCTION Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.SUBUNIT Monomer. Homodimer. Homomultimers. Interacts with SEMG1 (via 164-283 AA). Interacts with LTF. Found in a complex with LTF, CLU, EPPIN and SEMG1.SUBCELLULAR LOCATION Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.ALTERNATIVE PRODUCTS In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.DOMAIN The BPTI/Kunitz inhibitor domain is required for elastase inhibitory activity. BPTI/Kunitz inhibitor and WAP domains are involved in the protein antibacterial activity.MISCELLANEOUS Might be used as a target for male contraception.MISCELLANEOUS Lacks a cleavable signal sequence.MISCELLANEOUS Based on a readthrough transcript which may produce a EPPIN-WFDC6 fusion protein. |
| description | recommendedName: Eppin alternativeName: Cancer/testis antigen 71 shortName: CT71 alternativeName: Epididymal protease inhibitor alternativeName: Protease inhibitor WAP7 alternativeName: Serine protease inhibitor-like with Kunitz and WAP domains 1 alternativeName: WAP four-disulfide core domain protein 7 |
| geneName | EPPIN SPINLW1 WAP7 WFDC7 |
| identifier | O95925 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Antimicrobial Disulfide bond Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | EPPIN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996547] ENSEMBL:ENSG00000101448 EPPIN [Homo sapiens] [ReferenceDNASequence:8996546] ENSEMBL:ENSG00000249139 EPPIN [Homo sapiens] |
| secondaryIdentifier | EPPI_HUMAN A6PVD6 Q86TP9 Q96SD7 Q9HD30 |
| sequenceLength | 133 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:146986] UniProt:O95925-2 EPPIN [Homo sapiens] [ReferenceIsoform:402192] UniProt:O95925-1 EPPIN [Homo sapiens] [ReferenceIsoform:8967836] UniProt:O95925-3 EPPIN [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6810609] hC-EPPIN [sperm plasma membrane] [Homo sapiens] |
| (referenceSequence) | [InterChainCrosslinkedResidue:6810680] Inter-chain Crosslink via L-cystine (cross-link) at unknown and 239 |
| (secondReferenceSequence) | [InterChainCrosslinkedResidue:6810684] Inter-chain Crosslink via L-cystine (cross-link) at 239 and unknown |
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No pathways have been reviewed or authored by UniProt:O95925 EPPIN (54398)
