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Details on Person UniProt:O95936 EOMES
| Class:Id | ReferenceGeneProduct:54344 |
|---|---|
| _chainChangeLog | chain:1-686 added on Fri February 6 2015 |
| _displayName | UniProt:O95936 EOMES |
| _timestamp | 2025-05-21 21:05:09 |
| chain | chain:1-686 |
| checksum | 1A6BA0763C5A6681 |
| comment | FUNCTION Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017).INTERACTION Expressed in CD8+ T-cells.DEVELOPMENTAL STAGE Detected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within the mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development.INDUCTION Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4.DISEASE A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.MISCELLANEOUS Dubious isoform produced through aberrant splice sites. |
| description | recommendedName: Eomesodermin homolog alternativeName: T-box brain protein 2 shortName: T-brain-2 shortName: TBR-2 |
| geneName | EOMES TBR2 |
| identifier | O95936 |
| isSequenceChanged | FALSE |
| keyword | Activator Adaptive immunity Alternative splicing Chromosomal rearrangement Developmental protein Differentiation DNA-binding Gastrulation Immunity Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | EOMES |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2888886] ENSEMBL:ENSG00000163508 EOMES [Homo sapiens] |
| secondaryIdentifier | EOMES_HUMAN B7Z4I2 B7ZA51 G3XAI5 Q8TAZ2 Q9UPM7 |
| sequenceLength | 686 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8967832] UniProt:O95936-1 EOMES [Homo sapiens] [ReferenceIsoform:8967833] UniProt:O95936-2 EOMES [Homo sapiens] [ReferenceIsoform:8967834] UniProt:O95936-3 EOMES [Homo sapiens] [ReferenceIsoform:8967835] UniProt:O95936-4 EOMES [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:452232] EOMES [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95936 EOMES (54344)
