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Details on Person UniProt:P98073 TMPRSS15
| Class:Id | ReferenceGeneProduct:54340 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-784 added on Fri February 6 2015;chain:785-1019 added on Fri February 6 2015;initiator methionine:1 for 54340 removed on Fri Nov 03 2023;initiator methionine: for 54340 added on Fri Nov 03 2023;initiator methionine: for 54340 removed on Fri Aug 15 2025;initiator methionine:1 for 54340 added on Fri Aug 15 2025 |
| _displayName | UniProt:P98073 TMPRSS15 |
| _timestamp | 2025-08-15 22:00:15 |
| chain | initiator methionine:1 chain:2-784 chain:785-1019 |
| checksum | 45288F0636E5EC52 |
| comment | FUNCTION Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.CATALYTIC ACTIVITY Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.SUBUNIT Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.SUBCELLULAR LOCATION Intestinal brush border.PTM The chains are derived from a single precursor that is cleaved by a trypsin-like protease.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1 family. |
| description | recommendedName: Enteropeptidase ecNumber: 3.4.21.9 alternativeName: Enterokinase alternativeName: Serine protease 7 alternativeName: Transmembrane protease serine 15 component recommendedName: Enteropeptidase non-catalytic heavy chain /component component recommendedName: Enteropeptidase catalytic light chain /component |
| geneName | TMPRSS15 ENTK PRSS7 |
| identifier | P98073 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disulfide bond Glycoprotein Hydrolase Lipoprotein Membrane Myristate Protease Proteomics identification Reference proteome Repeat Serine protease Signal-anchor Transmembrane Transmembrane helix Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TMPRSS15 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002327] ENSEMBL:ENSG00000154646 TMPRSS15 [Homo sapiens] |
| secondaryIdentifier | ENTK_HUMAN Q2NKL7 |
| sequenceLength | 1019 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8985734] TMPRSS15 L chain [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8985742] TMPRSS15 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8985754] TMPRSS15 H chain [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P98073 TMPRSS15 (54340)
