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Details on Person UniProt:Q14542 SLC29A2

Class:Id	ReferenceGeneProduct:54338
_chainChangeLog	chain:1-456 added on Sat February 7 2015
_displayName	UniProt:Q14542 SLC29A2
_timestamp	2024-11-03 19:38:42
chain	chain:1-456
checksum	ABCBD244306708E1
comment	FUNCTION Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Functions as a Na(+)-independent, passive transporter (PubMed:9478986). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:16214850, PubMed:21795683). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (PubMed:12527552). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (PubMed:23639800). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity).FUNCTION Non functional nucleoside transporter protein for adenosine or thymidine transport. Does not express on cell membrane.CATALYTIC ACTIVITY inosine(in) = inosine(out)CATALYTIC ACTIVITY adenosine(in) = adenosine(out)CATALYTIC ACTIVITY uridine(out) = uridine(in)CATALYTIC ACTIVITY thymidine(in) = thymidine(out)CATALYTIC ACTIVITY hypoxanthine(out) = hypoxanthine(in)CATALYTIC ACTIVITY adenine(out) = adenine(in)CATALYTIC ACTIVITY cytidine(in) = cytidine(out)CATALYTIC ACTIVITY thymine(out) = thymine(in)CATALYTIC ACTIVITY uracil(in) = uracil(out)CATALYTIC ACTIVITY guanine(out) = guanine(in)CATALYTIC ACTIVITY guanosine(in) = guanosine(out)BIOPHYSICOCHEMICAL PROPERTIES Localized to the apical membrane of Sertoli cells.ALTERNATIVE PRODUCTS Highly expressed in skeletal muscle (PubMed:9478986). Expressed in liver, lung, placenta, brain, heart, kidney and ovarian tissues (PubMed:9478986). Expressed in testis at the blood-brain-barrier (PubMed:23639800).PTM Glycosylated.MISCELLANEOUS Transport activity is insensitive to nanomolar concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) (PubMed:10722669, PubMed:12590919, PubMed:21795683, PubMed:9396714, PubMed:9478986). Inhibited by higher concentrations of NBMPR (1uM-10uM) (PubMed:10722669, PubMed:12590919, PubMed:9396714, PubMed:9478986).MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.CAUTION The nuclear function of SLC29A2/ENT2 is unclear. A study reported that under proliferative conditions, two SLC29A2/ENT2 nuclear isoforms recruited SLC29A2/ENT2 to the nuclear envelope in order to translocate nucleosides into the nucleus for incorporation into DNA during replication (PubMed:27271752). However, the physiological existence of these isoforms has yet to be proven.SEQUENCE CAUTION Wrong choice of CDS.
description	recommendedName: fullName evidence="15"Equilibrative nucleoside transporter 2 shortName evidence="15"hENT2 alternativeName: fullName evidence="14"36 kDa nucleolar protein HNP36 alternativeName: fullName evidence="14"Delayed-early response protein 12 alternativeName: fullName evidence="16"Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter shortName evidence="16"Equilibrative NBMPR-insensitive nucleoside transporter alternativeName: Hydrophobic nucleolar protein, 36 kDa alternativeName: fullName evidence="14"Nucleoside transporter, ei-type alternativeName: fullName evidence="13"Solute carrier family 29 member 2
geneName	SLC29A2 DER12 ENT2 HNP36
identifier	Q14542
isSequenceChanged	FALSE
keyword	Alternative splicing Cell membrane Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	SLC29A2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9003800] ENSEMBL:ENSG00000174669 SLC29A2 [Homo sapiens]
secondaryIdentifier	S29A2_HUMAN B3KPY7 G5E943 O43530 Q52M84 Q96R00 Q9UPE0
sequenceLength	456
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:153492] UniProt:Q14542-2 SLC29A2 [Homo sapiens] [ReferenceIsoform:405721] UniProt:Q14542-1 SLC29A2 [Homo sapiens] [ReferenceIsoform:8964960] UniProt:Q14542-3 SLC29A2 [Homo sapiens] [ReferenceIsoform:9841332] UniProt:Q14542-4 SLC29A2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:54337] SLC29A2 [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q14542 SLC29A2 (54338)