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Details on Person UniProt:Q5SGK3 Aox2
| Class:Id | ReferenceGeneProduct:5433715 |
|---|---|
| _chainChangeLog | chain:1-1345 added on Fri February 6 2015 |
| _displayName | UniProt:Q5SGK3 Aox2 |
| _timestamp | 2025-02-21 20:06:22 |
| chain | chain:1-1345 |
| checksum | 6D3FA441A3F6F92C |
| comment | FUNCTION Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Cannot use hypoxanthine as substrate.CATALYTIC ACTIVITY an aldehyde + O2 + H2O = a carboxylate + H2O2 + H(+)COFACTOR Binds 2 [2Fe-2S] clusters per subunit.COFACTOR Binds 1 FAD per subunit.COFACTOR Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.SUBUNIT Homodimer.SUBCELLULAR LOCATION Expressed in olfactory mucosa epithelium (at protein level). Detected in skin.MISCELLANEOUS AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164).SIMILARITY Belongs to the xanthine dehydrogenase family. |
| created | [InstanceEdit:5433710] Weiser, JD |
| description | recommendedName: Aldehyde oxidase 2 ecNumber: 1.2.3.1 alternativeName: Aldehyde oxidase homolog 3 alternativeName: Azaheterocycle hydroxylase 2 ecNumber: 1.17.3.- |
| geneName | Aox2 Aoh3 Aox3l1 |
| identifier | Q5SGK3 |
| isSequenceChanged | FALSE |
| keyword | 2Fe-2S Cytoplasm FAD Flavoprotein Iron Iron-sulfur Metal-binding Molybdenum Oxidoreductase Reference proteome |
| modified | [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Aox2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | AOXB_MOUSE B9EKC6 |
| sequenceLength | 1345 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q5SGK3 Aox2 (5433715)
