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Details on Person Activation of tumor necrosis factor receptor 1 (TNFR1) can t...
| Class:Id | Summation:5433117 |
|---|---|
| _displayName | Activation of tumor necrosis factor receptor 1 (TNFR1) can t... |
| _timestamp | 2015-01-06 22:10:22 |
| created | [InstanceEdit:5433116] Shamovsky, V, 2014-05-12 |
| literatureReference | [LiteratureReference:5364203] NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro [LiteratureReference:140979] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes [LiteratureReference:5364079] Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling [LiteratureReference:5364181] Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles [LiteratureReference:5357965] Pro-caspase-3 is a major physiologic target of caspase-8 [LiteratureReference:141306] Caspase-10 is an initiator caspase in death receptor signaling [LiteratureReference:141160] Mechanisms of caspase activation |
| modified | [InstanceEdit:5660769] Shamovsky, V, 2015-01-06 |
| text | Activation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce cell survival or cell death (Ward C et al. 1999; Micheau O and Tschopp J 2003; Widera D et al. 2006). While pro-survival signaling is initiated and regulated via the activated TNFR1 receptor complex at the cell membrane, cell death signals are induced upon the release of TRADD:TRAF2:RIP1 complex from the membrane to the cytosol where it forms death-inducing signaling complex (DISC) (Micheau O and Tschopp J 2003; Schneider-Brachert W et al. 2004). Upon apoptotic stimulation procaspase-8 or 10 is recruited into the DISC, and close proximity promotes the dimerization, autocatalytic processing, and activation of the initiator caspase-8 (and/or caspase-10) (Wang J et al. 2001; Boatright KM and Salvesen GS 2003). The initiator caspases then process and activate the downstream effector caspases such as caspase-3 in a proteolytic cascade (Stennicke HR et al. 1998). The effector caspases in turn cleave many diverse substrates, ultimately inducing cell death. |
| (summation) | [Pathway:5357786] TNFR1-induced proapoptotic signaling [Homo sapiens] |
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