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Details on Person SFTPA/SFTPD binds TLR4:LY96

Class:Id	Reaction:5432852
_displayName	SFTPA/SFTPD binds TLR4:LY96
_doRelease	TRUE
_timestamp	2016-05-19 16:46:49
authored	[InstanceEdit:6797423] Shamovsky, Veronica, 2015-09-12
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5432863] Shamovsky, Veronica, 2014-05-12
edited	[InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10
input	[Complex:166050] TLR4:LY96 [plasma membrane] [Homo sapiens] [DefinedSet:391108] SFTPA oligomer, SFTPD oligomer [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5432773] Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization [LiteratureReference:391070] Surfactant proteins SP-A and SP-D: structure, function and receptors [LiteratureReference:5432811] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors [LiteratureReference:5432816] Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide
modified	[InstanceEdit:6793917] Shamovsky, Veronica, 2015-09-04 [InstanceEdit:6797470] Shamovsky, Veronica, 2015-09-12 [InstanceEdit:6809178] Shamovsky, Veronica, 2015-11-09 [InstanceEdit:6810019] Shamovsky, Veronica, 2015-11-13 [InstanceEdit:6810045] Shamovsky, Veronica, 2015-11-13 [InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10 [InstanceEdit:8870532] Shamovsky, Veronica, 2016-05-10 [InstanceEdit:8870808] Shamovsky, Veronica, 2016-05-12 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SFTPA/SFTPD binds TLR4:LY96 SFTPA/SFTPD binds TLR4:MD2
output	[Complex:5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:6797517] D'Eustachio, Peter, 2015-09-12 [InstanceEdit:8870806] Granucci, Francesca, Zanoni, Ivan
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873505] R-HSA-5432852.3
summation	[Summation:6797472] The hydrophilic pulmonary surfactant proteins SP-A (SFTPA) a...
(hasEvent)	[Pathway:5686938] Regulation of TLR by endogenous ligand [Homo sapiens]
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No pathways have been reviewed or authored by SFTPA/SFTPD binds TLR4:LY96 (5432852)