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Details on Person Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) ...
| Class:Id | Summation:5432699 |
|---|---|
| _displayName | Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) ... |
| _timestamp | 2014-08-18 13:29:44 |
| created | [InstanceEdit:5432697] Jassal, Bijay, 2014-05-12 |
| modified | [InstanceEdit:5467309] Jassal, Bijay, 2014-05-16 [InstanceEdit:5467319] Jassal, Bijay, 2014-05-16 [InstanceEdit:5618014] Jassal, Bijay, 2014-08-18 |
| text | Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) are dimeric, cytosolic, NADPH-dependent enzymes able to catalyse the reduction of aflatoxin B1 dialdehyde (AFBDHO) to aflatoxin B1-6,8-dialcohol (AFBDOH) (Ellis et al. 2003, Bodreddigari et al. 2008, Ireland et al. 1998, Guengerich et al. 2001). AKRs can turnover a vast range of substrates, including drugs, carcinogens, and reactive aldehydes. They play central roles in the metabolism of these agents, leading to either their bioactivation or detoxication (Jin & Penning 2007). The dialcohol is excreted in urine by conjugation with glucuronide (not shown here). |
| (summation) | [Reaction:5423637] AKR dimers reduce AFBDHO to AFBDOH [Homo sapiens] |
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No pathways have been reviewed or authored by Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) ... (5432699)
