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Details on Person UniProt:Q15717 ELAVL1

Class:Id	ReferenceGeneProduct:54274
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-326 added on Fri February 6 2015;initiator methionine:1 for 54274 removed on Fri Nov 03 2023;initiator methionine: for 54274 added on Fri Nov 03 2023;initiator methionine: for 54274 removed on Fri Aug 15 2025;initiator methionine:1 for 54274 added on Fri Aug 15 2025
_displayName	UniProt:Q15717 ELAVL1
_timestamp	2025-08-15 22:07:44
chain	initiator methionine:1 chain:2-326
checksum	0B86143805264DEF
comment	FUNCTION RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010).SUBUNIT Monomer and homodimer (in vitro) (PubMed:17632515, PubMed:20219472). Interacts with ANP32A (PubMed:11729309). Interacts with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1 (PubMed:19029303). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with IGF2BP1; the interaction is enhanced by SEPIN14P20 peptide RBPR (PubMed:29476152, PubMed:32245947). Interacts with IGF2BP2 and IGF2BP3 (PubMed:23640942, PubMed:29476152). Interacts with HNRNPL (PubMed:18161049). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:14731398). Interacts with ILF3; this interaction occurs in a RNA-dependent manner (PubMed:14731398). Interacts with PLEKHN1 (PubMed:18191643, PubMed:27616329). Interacts with SHFL; the interaction increases in presence of RNA (PubMed:27974568). Interacts with YBX1; interaction recruits ELAVL1 on C5-methylcytosine (m5C)-containing mRNAs, thereby promoting mRNA stability (PubMed:31358969). Interacts with FXR1 (PubMed:30067974).INTERACTION Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462). Localizes to the stress granules in the presence of PLEKHN1 (By similarity).ALTERNATIVE PRODUCTS Ubiquitous. Detected in brain, liver, thymus and muscle.DOMAIN The first RRM (RNA recognition motif) domain is essential for binding to AU-rich elements.PTM Phosphorylated by MAPKAPK2 (PubMed:14517288). Phosphorylated by PRKCD (PubMed:18285462).PTM Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.SIMILARITY Belongs to the RRM elav family.
description	recommendedName: ELAV-like protein 1 alternativeName: Hu-antigen R shortName evidence="25"HuR
geneName	ELAVL1 HUR
identifier	Q15717
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat RNA-binding Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	ELAVL1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8992429] ENSEMBL:ENSG00000066044 ELAVL1 [Homo sapiens]
secondaryIdentifier	ELAV1_HUMAN B4DVB8 Q53XN6 Q9BTT1
sequenceLength	326
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8970978] UniProt:Q15717-1 ELAVL1 [Homo sapiens] [ReferenceIsoform:8970979] UniProt:Q15717-2 ELAVL1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:450376] p-S158,S221-ELAVL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:450448] p-S221,S318-ELAVL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:450532] p-S221,S318-ELAVL1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:450576] p-S158,S221-ELAVL1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:450582] ELAVL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:450601] ELAVL1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8980135] K63polyUb-ELAVL1 [plasma membrane] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:450383] O-phospho-L-serine at 158 [ModifiedResidue:450482] O-phospho-L-serine at 221 [ModifiedResidue:450553] O-phospho-L-serine at 318 [GroupModifiedResidue:8983604] ubiquitinylated lysine (K63polyUb [endosome membrane]) at 63
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No pathways have been reviewed or authored by UniProt:Q15717 ELAVL1 (54274)