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Details on Person UniProt:Q9HB03 ELOVL3
| Class:Id | ReferenceGeneProduct:54268 |
|---|---|
| _chainChangeLog | chain:1-270 added on Fri February 6 2015 |
| _displayName | UniProt:Q9HB03 ELOVL3 |
| _timestamp | 2025-05-21 21:48:51 |
| chain | chain:1-270 |
| checksum | 0C6C8F1E7B5DE8B1 |
| comment | FUNCTION Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.CATALYTIC ACTIVITY a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoACATALYTIC ACTIVITY eicosanoyl-CoA + malonyl-CoA + H(+) = 3-oxodocosanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY hexadecanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctadecanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY octadecanoyl-CoA + malonyl-CoA + H(+) = 3-oxoeicosanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoACATALYTIC ACTIVITY docosanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetracosanoyl-CoA + CO2 + CoACATALYTIC ACTIVITY tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoAPATHWAY Lipid metabolism; polyunsaturated fatty acid biosynthesis.SUBUNIT Interacts with TECR.SUBCELLULAR LOCATION Testis.DOMAIN The C-terminal di-lysine motif may confer endoplasmic reticulum localization.PTM N-Glycosylated.SIMILARITY Belongs to the ELO family. ELOVL3 subfamily. |
| description | recommendedName: fullName evidence="1"Very long chain fatty acid elongase 3 ecNumber evidence="1 2 3"2.3.1.199 alternativeName: fullName evidence="1"3-keto acyl-CoA synthase ELOVL3 alternativeName: Cold-inducible glycoprotein of 30 kDa alternativeName: fullName evidence="1"ELOVL fatty acid elongase 3 shortName evidence="1"ELOVL FA elongase 3 alternativeName: fullName evidence="1"Elongation of very long chain fatty acids protein 3 alternativeName: fullName evidence="1"Very long chain 3-ketoacyl-CoA synthase 3 alternativeName: fullName evidence="1"Very long chain 3-oxoacyl-CoA synthase 3 |
| geneName | ELOVL3 CIG30 |
| identifier | Q9HB03 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Glycoprotein Lipid biosynthesis Lipid metabolism Membrane Reference proteome Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | ELOVL3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5641218] ENSEMBL:ENSG00000119915 ELOVL3 [Homo sapiens] |
| secondaryIdentifier | ELOV3_HUMAN Q5VZL3 Q8N180 |
| sequenceLength | 270 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:548785] ELOVL3 [endoplasmic reticulum membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9HB03 ELOVL3 (54268)
