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Details on Person UniProt:P19957 PI3
| Class:Id | ReferenceGeneProduct:54246 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;propeptide:23-60 added on Fri February 6 2015;chain:61-117 added on Fri February 6 2015 |
| _displayName | UniProt:P19957 PI3 |
| _timestamp | 2024-11-03 20:00:41 |
| chain | signal peptide:1-22 propeptide:23-60 chain:61-117 |
| checksum | A51D46257E5B03EF |
| comment | FUNCTION Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).SUBCELLULAR LOCATION Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins. |
| description | recommendedName: Elafin alternativeName: Elastase-specific inhibitor shortName: ESI alternativeName: Peptidase inhibitor 3 shortName: PI-3 alternativeName: Protease inhibitor WAP3 alternativeName: Skin-derived antileukoproteinase shortName: SKALP alternativeName: WAP four-disulfide core domain protein 14 |
| geneName | PI3 WAP3 WFDC14 |
| identifier | P19957 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disulfide bond Protease inhibitor Proteomics identification Reference proteome Repeat Secreted Serine protease inhibitor Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PI3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994198] ENSEMBL:ENSG00000124102 PI3 [Homo sapiens] |
| secondaryIdentifier | ELAF_HUMAN E1P618 Q6FG74 |
| sequenceLength | 117 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6810802] PI3(61-117) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6810812] PI3(23-117) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6814198] PI3(61-117) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8934845] PI3(61-117) [cornified envelope] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P19957 PI3 (54246)
