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Details on Person CYP1A2, 3A4 oxidise AFB1 to AFNBO

Class:Id	Reaction:5423672
_displayName	CYP1A2, 3A4 oxidise AFB1 to AFNBO
_doRelease	TRUE
_timestamp	2014-11-20 02:35:16
authored	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
catalystActivity	[CatalystActivity:5423617] monooxygenase activity of CYP1A2,3A4 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
edited	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
input	[SimpleEntity:5423605] AFB1 [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:5423623] The endo-8,9-epoxide of aflatoxin B1: a new metabolite [LiteratureReference:5423649] Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes
modified	[InstanceEdit:5467309] Jassal, Bijay, 2014-05-16 [InstanceEdit:5545506] Jassal, Bijay, 2014-05-22 [InstanceEdit:5566525] Jassal, Bijay, 2014-05-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP1A2, 3A4 oxidise AFB1 to AFNBO
output	[SimpleEntity:5423663] AFNBO [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5545505] D'Eustachio, Peter, 2014-05-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644366] R-HSA-5423672.2
summation	[Summation:5423665] Aflatoxin B1 (AFB1) requires microsomal oxidation to produce...
(hasEvent)	[Pathway:5423646] Aflatoxin activation and detoxification [Homo sapiens]
(precedingEvent)	[Reaction:5423653] MGST trimers transfer GS from GSH to AFXBO and AFNBO [Homo sapiens]
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No pathways have been reviewed or authored by CYP1A2, 3A4 oxidise AFB1 to AFNBO (5423672)