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Details on Person AKR dimers reduce AFBDHO to AFBDOH

Class:Id	Reaction:5423637
_displayName	AKR dimers reduce AFBDHO to AFBDOH
_doRelease	TRUE
_timestamp	2014-11-20 02:47:54
authored	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
catalystActivity	[CatalystActivity:5423725] alcohol dehydrogenase (NADP+) activity of AKR dimers [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
edited	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
input	[SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:5423727] AFBDHO [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5432696] Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase [LiteratureReference:5432686] Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3 [LiteratureReference:5432702] Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter [LiteratureReference:5432681] Aldo-keto reductases and bioactivation/detoxication [LiteratureReference:5617164] Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases
modified	[InstanceEdit:5423722] Jassal, Bijay, 2014-05-09 [InstanceEdit:5432697] Jassal, Bijay, 2014-05-12 [InstanceEdit:5467309] Jassal, Bijay, 2014-05-16 [InstanceEdit:5545506] Jassal, Bijay, 2014-05-22 [InstanceEdit:5566525] Jassal, Bijay, 2014-05-23 [InstanceEdit:5617159] Jassal, Bijay, 2014-08-05 [InstanceEdit:5617163] Jassal, Bijay, 2014-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKR dimers reduce AFBDHO to AFBDOH
output	[SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:5423729] AFBDOH [cytosol]
precedingEvent	[Reaction:5423694] AFBDHD hydrolyses non-enzymatically to AFBDHO [Homo sapiens] [Reaction:5423656] AFXBO hydrolyses non-enzymatically to AFBDHD [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5545505] D'Eustachio, Peter, 2014-05-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644830] R-HSA-5423637.2
summation	[Summation:5432699] Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) ...
(hasEvent)	[Pathway:5423646] Aflatoxin activation and detoxification [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786003] Update Tracker - [Reaction:5423637] AKR dimers reduce AFBDHO to AFBDOH - v50:[addLiteratureReference, modifyText]
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