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Details on Person UniProt:P01133 EGF
| Class:Id | ReferenceGeneProduct:54210 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;chain:23-1207 added on Fri February 6 2015;chain:971-1023 added on Fri February 6 2015 |
| _displayName | UniProt:P01133 EGF |
| _timestamp | 2024-11-03 20:14:16 |
| chain | signal peptide:1-22 chain:23-1207 chain:971-1023 |
| checksum | 3C787F1D405CFAF1 |
| comment | FUNCTION EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).SUBUNIT Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).INTERACTION Expressed in kidney, salivary gland, cerebrum and prostate.PTM O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Epidermal growth factor entry |
| description | recommendedName: Pro-epidermal growth factor shortName: EGF component recommendedName: Epidermal growth factor alternativeName: Urogastrone /component |
| geneName | EGF |
| identifier | P01133 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond EGF-like domain Glycoprotein Growth factor Membrane Primary hypomagnesemia Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | EGF |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996539] ENSEMBL:ENSG00000138798 EGF [Homo sapiens] |
| secondaryIdentifier | EGF_HUMAN B4DRK7 E7EVD2 E9PBF0 Q52LZ6 |
| sequenceLength | 1207 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976463] UniProt:P01133-1 EGF [Homo sapiens] [ReferenceIsoform:8976464] UniProt:P01133-2 EGF [Homo sapiens] [ReferenceIsoform:8976465] UniProt:P01133-3 EGF [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:54209] Pro-EGF [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:139875] Pro-EGF [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:179863] EGF [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:179888] Pro-EGF [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8869086] EGF [clathrin-coated endocytic vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01133 EGF (54210)
