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Details on Person MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA

Class:Id	Reaction:5419264
_displayName	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
_doRelease	TRUE
_timestamp	2025-06-02 14:49:14
authored	[InstanceEdit:5389860] May, Bruce, 2014-04-30
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:5419278] May, Bruce, 2014-05-03
edited	[InstanceEdit:5389860] May, Bruce, 2014-04-30
input	[SimpleEntity:113573] GTP [mitochondrial matrix] [DefinedSet:5432633] MTRF1L, ICT1 [mitochondrial matrix] [Homo sapiens] [Complex:9941868] 55S ribosome:mRNA (UAA,UAG stop codon):peptidyl-tRNA at P-site [mitochondrial inner membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5432614] HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG [LiteratureReference:5432610] mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG
modified	[InstanceEdit:5432639] May, Bruce, 2014-05-11 [InstanceEdit:5487090] May, Bruce, 2014-05-17 [InstanceEdit:5621502] May, Bruce, 2014-08-29 [InstanceEdit:5621505] May, Bruce, 2014-08-29 [InstanceEdit:5621509] May, Bruce, 2014-08-29 [InstanceEdit:5624187] May, Bruce, 2014-09-20 [InstanceEdit:5624365] May, Bruce, 2014-09-27 [InstanceEdit:5624373] May, Bruce, 2014-09-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9938530] May, Bruce, 2025-02-18 [InstanceEdit:9941879] May, Bruce, 2025-03-11 [InstanceEdit:9953423] May, Bruce, 2025-06-02
name	MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
output	[Complex:5419280] 55S ribosome:mRNA (UAA,UAG stop codon):peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[Reaction:5419279] Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) [Homo sapiens] [Reaction:5419261] 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2014-09-30
reviewed	[InstanceEdit:5621503] Chrzanowska-Lightowlers, Zofia M A, 2014-08-29 [InstanceEdit:5624178] Spremulli, Linda L, 2014-09-20 [InstanceEdit:9953420] May, Bruce, 2025-06-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622656] R-HSA-5419264.4
structureModified	[InstanceEdit:9941879] May, Bruce, 2025-03-11
summation	[Summation:5487082] MTRF1L (mtRF1a) binds the stop codons UAA and UAG of the mRN...
(hasEvent)	[Pathway:5419276] Mitochondrial translation termination [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5419271] 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785903] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v51:[modifyText] [_UpdateTracker:9939808] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v92:[addLiteratureReference, modifyText] [_UpdateTracker:9953701] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v93:[add_removeInput]
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No pathways have been reviewed or authored by MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (5419264)