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Details on Person UniProt:P24534 EEF1B2
| Class:Id | ReferenceGeneProduct:54170 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-225 added on Sat February 7 2015;initiator methionine:1 for 54170 removed on Fri Nov 03 2023;initiator methionine: for 54170 added on Fri Nov 03 2023;initiator methionine: for 54170 removed on Fri Aug 15 2025;initiator methionine:1 for 54170 added on Fri Aug 15 2025 |
| _displayName | UniProt:P24534 EEF1B2 |
| _timestamp | 2025-08-15 21:44:58 |
| chain | initiator methionine:1 chain:2-225 |
| checksum | CDE763ADBF127822 |
| comment | FUNCTION Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity).SUBUNIT EF-1 is composed of 4 subunits: alpha, beta (alpha subunit of the eEF1B subcomplex), delta (beta subunit of the eEF1B subcomplex), and gamma (gamma subunit of the eEF1B subcomplex) (Probable). Interacts with elongation factor EEF1A1 (By similarity).INTERACTION By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.PTM Phosphorylation affects the GDP/GTP exchange rate.SIMILARITY Belongs to the EF-1-beta/EF-1-delta family. |
| description | recommendedName: Elongation factor 1-beta shortName: EF-1-beta alternativeName: fullName evidence="7"eEF-1B alpha |
| geneName | EEF1B2 EEF1B EF1B |
| identifier | P24534 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Elongation factor Isopeptide bond Phosphoprotein Protein biosynthesis Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | EEF1B2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961042] ENSEMBL:ENSG00000114942 EEF1B2 [Homo sapiens] |
| secondaryIdentifier | EF1B_HUMAN A8K795 Q6IBH9 |
| sequenceLength | 225 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:156926] EEF1B2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8961241] EEF1B2 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P24534 EEF1B2 (54170)
