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Details on Person UniProt:P78364 PHC1
| Class:Id | ReferenceGeneProduct:54160 |
|---|---|
| _chainChangeLog | chain:1-1004 added on Fri February 6 2015 |
| _displayName | UniProt:P78364 PHC1 |
| _timestamp | 2024-11-03 19:57:57 |
| chain | chain:1-1004 |
| checksum | D53764F80931A938 |
| comment | FUNCTION Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.SUBUNIT Homodimer. Component of a PRC1-like complex (PubMed:12167701, PubMed:19636380, PubMed:21282530). Interacts with RNF2 and CBX7 (By similarity). Interacts with PHC2, PHC2 and BMI1 (By similarity).INTERACTION The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Polyhomeotic-like protein 1 shortName: hPH1 alternativeName: Early development regulatory protein 1 |
| geneName | PHC1 EDR1 PH1 |
| identifier | P78364 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Developmental protein Disease variant DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Primary microcephaly Proteomics identification Reference proteome Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PHC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995044] ENSEMBL:ENSG00000111752 PHC1 [Homo sapiens] |
| secondaryIdentifier | PHC1_HUMAN D3DUV4 Q8WVM3 Q9BU63 |
| sequenceLength | 1004 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:389111] PHC1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P78364 PHC1 (54160)
