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Details on Person UniProt:Q13627 DYRK1A

Class:Id	ReferenceGeneProduct:54046
_chainChangeLog	chain:1-763 added on Sat February 7 2015
_displayName	UniProt:Q13627 DYRK1A
_timestamp	2026-02-20 22:54:04
chain	chain:1-763
checksum	7C3A52A3CBB04FB5
comment	FUNCTION Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)ACTIVITY REGULATION Inhibited by RANBP9 (PubMed:14500717). Inhibited by harmine, leucettamine B and leucettine L41 (PubMed:22998443).SUBUNIT Interacts with RAD54L2/ARIP4 (PubMed:39028815). Interacts with CRY2 (By similarity). Interacts with RANBP9 (PubMed:14500717). Interacts with WDR68 (PubMed:14593110). Interacts with SIRT1 (By similarity).SUBUNIT (Microbial infection) Interacts with human adenovirus 5 E1A protein (PubMed:23864635).INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.DEVELOPMENTAL STAGE Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.DOMAIN The polyhistidine repeats act as targeting signals to nuclear speckles.DOMAIN The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance its ability to phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).PTM Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
description	recommendedName: Dual specificity tyrosine-phosphorylation-regulated kinase 1A ecNumber evidence="21"2.7.11.23 ecNumber evidence="12 15 18 20 23"2.7.12.1 alternativeName: Dual specificity YAK1-related kinase alternativeName: HP86 alternativeName: fullName evidence="32 33"Protein kinase minibrain homolog shortName: MNBH shortName: hMNB
geneName	DYRK1A DYRK MNB MNBH
identifier	Q13627
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing ATP-binding Host-virus interaction Intellectual disability Kinase Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transcription Transcription regulation Transferase Tyrosine-protein kinase
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	DYRK1A
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8990659] ENSEMBL:ENSG00000157540 DYRK1A [Homo sapiens]
secondaryIdentifier	DYR1A_HUMAN O60769 Q92582 Q92810 Q9UNM5
sequenceLength	763
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:146645] UniProt:Q13627-2 DYRK1A [Homo sapiens] [ReferenceIsoform:146646] UniProt:Q13627-3 DYRK1A [Homo sapiens] [ReferenceIsoform:146647] UniProt:Q13627-4 DYRK1A [Homo sapiens] [ReferenceIsoform:146648] UniProt:Q13627-5 DYRK1A [Homo sapiens] [ReferenceIsoform:405648] UniProt:Q13627-1 DYRK1A [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:1362267] DYRK1A [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q13627 DYRK1A (54046)