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Details on Person UniProt:Q92997 DVL3
| Class:Id | ReferenceGeneProduct:53998 |
|---|---|
| _chainChangeLog | chain:1-716 added on Fri February 6 2015 |
| _displayName | UniProt:Q92997 DVL3 |
| _timestamp | 2024-11-03 19:36:09 |
| chain | chain:1-716 |
| checksum | B1A55EBF9507D06E |
| comment | FUNCTION Involved in the signal transduction pathway mediated by multiple Wnt genes.SUBUNIT Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2. Interacts with DCDC2. Interacts with FOXK1 and FOXK2 (PubMed:25805136). Interacts with DAAM2 (By similarity).INTERACTION Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.PTM Phosphorylated by CSNK1D.PTM Arginine methylation may function as a switch in regulation of function in Wnt signaling.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the DSH family. |
| description | recommendedName: Segment polarity protein dishevelled homolog DVL-3 shortName: Dishevelled-3 alternativeName: DSH homolog 3 |
| geneName | DVL3 KIAA0208 |
| identifier | Q92997 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Developmental protein Dwarfism Methylation Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DVL3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003500] ENSEMBL:ENSG00000161202 DVL3 [Homo sapiens] |
| secondaryIdentifier | DVL3_HUMAN B4E3E5 D3DNT0 O14642 Q13531 Q8N5E9 Q92607 |
| sequenceLength | 716 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968756] UniProt:Q92997-1 DVL3 [Homo sapiens] [ReferenceIsoform:8968757] UniProt:Q92997-2 DVL3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201678] DVL3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:201680] p-DVL3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3772400] pp-DVL3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:4652688] ub-DVL3 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3772386] phosphorylated residue at unknown position [GroupModifiedResidue:4652686] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q92997 DVL3 (53998)
