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Details on Person UniProt:O14641 DVL2
| Class:Id | ReferenceGeneProduct:53996 |
|---|---|
| _chainChangeLog | chain:1-736 added on Fri February 6 2015 |
| _displayName | UniProt:O14641 DVL2 |
| _timestamp | 2025-02-21 18:56:05 |
| chain | chain:1-736 |
| checksum | 4BAD95B6C3FE531B |
| comment | FUNCTION Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.SUBUNIT Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity). Interacts with DACT1 and FAM105B/otulin. Interacts with DCDC2. Interacts (when phosphorylated) with FOXK1 and FOXK2; the interaction induces DVL2 nuclear translocation (PubMed:25805136). Interacts with MAPK15 (By similarity). Interacts with PKD1 (via extracellular domain) (PubMed:27214281). Interacts with LMBR1L (By similarity). Interacts with IRS1 and IRS2; these interactions decrease 'Lys-63'-linked ubiquitination of DVL2 and stabilize DVL2 protein via suppressing its autophagy-mediated degradation (PubMed:24616100).INTERACTION Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).DOMAIN The DIX domain mediates homooligomerization.PTM Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).PTM Ubiquitinated via 'Lys-63'-linked polyubiquitin chains; leading to its autophagy-mediated degradation.SIMILARITY Belongs to the DSH family. |
| description | recommendedName: Segment polarity protein dishevelled homolog DVL-2 shortName: Dishevelled-2 alternativeName: DSH homolog 2 |
| geneName | DVL2 |
| identifier | O14641 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Cytoplasm Cytoplasmic vesicle Developmental protein Isopeptide bond Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | DVL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997129] ENSEMBL:ENSG00000004975 DVL2 [Homo sapiens] |
| secondaryIdentifier | DVL2_HUMAN D3DTN3 Q53XM0 |
| sequenceLength | 736 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201694] DVL2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:201706] p-DVL2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3772398] pp-DVL2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:4652689] ub-DVL2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5138444] p-DVL2 [clathrin-coated endocytic vesicle] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3772384] phosphorylated residue at unknown position [GroupModifiedResidue:4652687] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:O14641 DVL2 (53996)
