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Details on Person UniProt:P28562 DUSP1
| Class:Id | ReferenceGeneProduct:53956 |
|---|---|
| _chainChangeLog | chain:1-367 added on Fri February 6 2015 |
| _displayName | UniProt:P28562 DUSP1 |
| _timestamp | 2025-05-21 21:24:00 |
| chain | chain:1-367 |
| checksum | 11BD1D39A9FCD51F |
| comment | FUNCTION Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphateINTERACTION Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.INDUCTION By oxidative stress and heat shock.PTM Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.PTM 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. |
| description | recommendedName: fullName evidence="12"Dual specificity protein phosphatase 1 ecNumber evidence="1"3.1.3.16 ecNumber evidence="6"3.1.3.48 alternativeName: fullName evidence="11"Dual specificity protein phosphatase hVH1 alternativeName: Mitogen-activated protein kinase phosphatase 1 shortName: MAP kinase phosphatase 1 shortName: MKP-1 alternativeName: fullName evidence="10"Protein-tyrosine phosphatase CL100 |
| geneName | DUSP1 CL100 MKP1 PTPN10 VH1 |
| identifier | P28562 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell cycle Hydrolase Nucleus Phosphoprotein Protein phosphatase Proteomics identification Reference proteome Stress response Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | DUSP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002319] ENSEMBL:ENSG00000120129 DUSP1 [Homo sapiens] |
| secondaryIdentifier | DUS1_HUMAN D3DQL9 Q2V508 |
| sequenceLength | 367 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:203796] DUSP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:443794] DUSP1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P28562 DUSP1 (53956)
