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Details on Person UniProt:P32926 DSG3
| Class:Id | ReferenceGeneProduct:53922 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;propeptide:24-49 added on Fri February 6 2015;chain:50-999 added on Fri February 6 2015 |
| _displayName | UniProt:P32926 DSG3 |
| _timestamp | 2025-08-15 21:52:28 |
| chain | signal peptide:1-23 propeptide:24-49 chain:50-999 |
| checksum | 7553CC917E8719BA |
| comment | FUNCTION A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450).SUBUNIT Homodimer (PubMed:19717567). Part of a complex that contains DSG3, PKP1, YAP1 and YWHAG; the complex is required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes (PubMed:31835537). Interacts with PKP2 (PubMed:11790773). Interacts with CTNND1; the interaction facilitates DSG3 localization and retention at cell-cell junctions (PubMed:18343367). Interacts with CDH1; the interaction is required for CDH1 localization to developing adherens junctions (PubMed:22294297). Interacts with RAC1; the interaction is required for DSG3 translocation to cell-cell junctions, organization of cortical F-actin bundles and actin anchoring at cell-cell junctions (PubMed:22796473). Interacts with DSC3; the interaction may limit the interaction of DSC3 with p38MAPK family members and therefore repress p38MAPK signaling activation (By similarity).SUBCELLULAR LOCATION Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level) (PubMed:19717567). Expressed in skin and mucosa (at protein level) (PubMed:22294297, PubMed:30528827). Expressed in the basal layer of the outer root sheath of the telogen hair club, specifically at the cell membrane between the apex of the cells and the surrounding hair club (at protein level) (PubMed:9701552). Expression is less abundant between the lateral margins of the outer root sheath basal cells (at protein level) (PubMed:9701552). Also expressed in the tongue, tonsil and esophagus (PubMed:16740002).INDUCTION Induced in the hours following cyclic mechanical strain in keratinocytes.DOMAIN Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.DISEASE The disease may be caused by variants affecting the gene represented in this entry.MISCELLANEOUS Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3 (PubMed:1720352). Loss of expression at points of cell-cell contact between the basal and suprabasal layers in blisters and immediately adjacent to blisters in PV (PubMed:22294297). In a PV patient acantholysis extends from the epidermis of the scalp down the entire outer root sheath of mostly empty dilated hair follicles that contain only small residual unanchored hair shafts and necrotic detached cells (PubMed:9701552). Although hair loss is not a major phenotype in PV due to the lower number of hair follicles in telogen phase in humans, this would suggest DSG3 disruption results in hair follicle abnormalities (PubMed:9701552). |
| description | recommendedName: fullName evidence="18"Desmoglein-3 alternativeName: 130 kDa pemphigus vulgaris antigen shortName: PVA alternativeName: Cadherin family member 6 |
| geneName | DSG3 CDHF6 |
| identifier | P32926 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cell adhesion Cell junction Cell membrane Cleavage on pair of basic residues Cytoplasm Glycoprotein Membrane Metal-binding Proteomics identification Reference proteome Repeat Signal Tight junction Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DSG3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998269] ENSEMBL:ENSG00000134757 DSG3 [Homo sapiens] |
| secondaryIdentifier | DSG3_HUMAN A8K2V2 |
| sequenceLength | 999 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201590] DSG3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:202797] DSG3(782-999) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202803] DSG3(50-781) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8847723] DSG3 [cornified envelope] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P32926 DSG3 (53922)
