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Details on Person STAT3 activation in response to IL2 is contraverisal. Beadli...
| Class:Id | Summation:539009 |
|---|---|
| _displayName | STAT3 activation in response to IL2 is contraverisal. Beadli... |
| _timestamp | 2011-04-11 09:58:39 |
| created | [InstanceEdit:539015] Jupe, S, 2010-03-09 |
| literatureReference | [LiteratureReference:538997] MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells [LiteratureReference:539049] IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells [LiteratureReference:539036] A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6 [LiteratureReference:539019] What does Stat3 do? [LiteratureReference:539026] Serine phosphorylation of STATs |
| modified | [InstanceEdit:560555] Jupe, S, 2010-03-24 [InstanceEdit:919403] Jupe, S, 2010-08-04 [InstanceEdit:1213499] Jupe, S, 2011-02-11 [InstanceEdit:1248024] Jupe, S, 2011-04-11 |
| text | STAT3 activation in response to IL2 is contraverisal. Beadling et al. (1994) concluded that STAT1-4 are not activated in response to IL2. However other studies have suggested that STAT3 is activated in T cells in response to IL2 (Johnston et al. 1995) and appears to be partly responsible for IL-2 signal transduction (Akaishi et al. 1998). This activation process involves phosphorylation of Tyrosine-705 and is thought to be mediated by JAK1, which is known to activates STAT3 in response to IL6 (Guschin et al. 1995, Levy & Lee 2002). Tyrosine phosphorylation of STAT3 is required for dimerization, nuclear translocation, and DNA binding while the function of serine 727 phosphorylation, which is also know to occur downstream of IL-2, remains largely unknown. The mechanism for serine phosphorylation is independent of tyrosine phosphorylation. Several candidates have been proposed as the relevant kinase including MSK1 and/or a JNK (Zhang et al. 2001), ERK2 (Fung et al. 2003) p38MAPK and an H-7-sensitive kinase possibly PKC delta (Decker & Kovarik 2000). |
| (summation) | [Reaction:539002] DO NOT RELEASE - STAT3 is phosphorylated [Homo sapiens] |
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No pathways have been reviewed or authored by STAT3 activation in response to IL2 is contraverisal. Beadli... (539009)
