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Details on Person processing defective Hh variants are degraded by the proteasome

Class:Id	BlackBoxEvent:5387392
_displayName	processing defective Hh variants are degraded by the proteasome
_doRelease	TRUE
_timestamp	2018-11-28 18:29:53
authored	[InstanceEdit:5358461] Rothfels, Karen, 2014-03-28
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5387393] Rothfels, Karen, 2014-04-29
disease	[Disease:5358398] holoprosencephaly
edited	[InstanceEdit:5490367] D'Eustachio, Peter, 2014-05-19
entityFunctionalStatus	[EntityFunctionalStatus:9630079] gain_of_function of ub-SHH variants [cytosol]
input	[CandidateSet:5387369] ub-SHH variants [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [LiteratureReference:5359146] Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum
modified	[InstanceEdit:5483268] Rothfels, Karen, 2014-05-16 [InstanceEdit:5492217] Rothfels, Karen, 2014-05-20 [InstanceEdit:9630081] Rothfels, Karen, 2018-11-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	processing defective Hh variants are degraded by the proteasome
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5387389] Hh processing variants are translocated to the cytosol in a VCP-dependent manner [Homo sapiens] [Reaction:5483238] Hh processing variants are ubiquitinated [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644920] R-HSA-5387392.3
summation	[Summation:5387380] After retrotranslocation to the cytosol, processing-defectiv...
(hasEvent)	[Pathway:5362768] Hh mutants are degraded by ERAD [Homo sapiens]
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No pathways have been reviewed or authored by processing defective Hh variants are degraded by the proteasome (5387392)