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Details on Person UniProt:O60673 REV3L
| Class:Id | ReferenceGeneProduct:53858 |
|---|---|
| _chainChangeLog | chain:1-3130 added on Fri February 6 2015 |
| _displayName | UniProt:O60673 REV3L |
| _timestamp | 2026-02-20 21:43:35 |
| chain | chain:1-3130 |
| checksum | 4FBAA214639DF3C6 |
| comment | FUNCTION Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.CATALYTIC ACTIVITY DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphateCOFACTOR Binds 1 [4Fe-4S] cluster.BIOPHYSICOCHEMICAL PROPERTIES kcat is 0.31 min(-1) for DNA synthesis by Pol-zeta4. kcat is 0.05 min(-1) for DNA synthesis by Pol-zeta2.SUBUNIT Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta. Forms a quaternary complex with POLK, MAD2L2 and REV1, where REV3L-bound MAD2L2 and POLK are able to bind simultaneously to REV1 forming the stable translesion synthesis (TLS) machinery therefore bridging the inserter and extender polymerases (PubMed:23143872).INTERACTION Ubiquitously expressed.DOMAIN Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.DOMAIN The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.SIMILARITY Belongs to the DNA polymerase type-B family. |
| description | recommendedName: DNA polymerase zeta catalytic subunit ecNumber evidence="9"2.7.7.7 alternativeName: Protein reversionless 3-like shortName: REV3-like shortName: hREV3 |
| geneName | REV3L POLZ REV3 |
| identifier | O60673 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure 4Fe-4S Alternative splicing DNA damage DNA repair DNA replication DNA-binding DNA-directed DNA polymerase Iron Iron-sulfur Metal-binding Nucleotidyltransferase Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | REV3L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002584] ENSEMBL:ENSG00000009413 REV3L [Homo sapiens] |
| secondaryIdentifier | REV3L_HUMAN O43214 Q5TC33 |
| sequenceLength | 3130 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:227503] UniProt:O60673-2 REV3L [Homo sapiens] [ReferenceIsoform:401717] UniProt:O60673-1 REV3L [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:110278] REV3L [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9943312] REV3L (GC B cell) [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O60673 REV3L (53858)
