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Details on Person POLB [nucleoplasm]
Class:Id EntityWithAccessionedSequence:53845
_displayName POLB [nucleoplasm]
_timestamp 2025-02-18 19:21:46
compartment [Compartment:7660] nucleoplasm
endCoordinate 335
modified [InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:113468] Schmidt, EE, 2004-05-17 11:31:25 [InstanceEdit:3132750] Wu, G, 2013-02-13 [InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:9938686] D'Eustachio, Peter, 2025-02-18
name POLB DNA polymerase beta (EC 2.7.7.7)
referenceEntity [ReferenceGeneProduct:53846] UniProt:P06746 POLB [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:371166] R-HSA-53845.2
startCoordinate 1
(activeUnit) [CatalystActivity:5649543] DNA-(apurinic or apyrimidinic site) endonuclease activity of POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] [CatalystActivity:5649635] DNA-directed DNA polymerase activity of LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] [CatalystActivity:5649728] DNA-directed DNA polymerase activity of NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] [CatalystActivity:5649731] DNA-(apurinic or apyrimidinic site) endonuclease activity of NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] [CatalystActivity:5649867] DNA-directed DNA polymerase activity of PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
(hasComponent) [Complex:110335] POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] [Homo sapiens] [Complex:110337] POLB:SSB-gap-dsDNA [nucleoplasm] [Homo sapiens] [Complex:110341] LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] [Homo sapiens] [Complex:110343] LIG3:XRCC1:POLB:dsDNA [nucleoplasm] [Homo sapiens] [Complex:5649715] NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5649722] NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] [Homo sapiens] [Complex:5649730] NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5649733] NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5649858] POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens]
(input) [Reaction:110360] Recruitment of POLB to the AP site [Homo sapiens] [Reaction:5649708] NEIL1,NEIL2 recruits POLB to incised AP site [Homo sapiens] [Reaction:5649854] Recruitment of POLB to oxidatively damaged AP site [Homo sapiens]
(output) [Reaction:110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 [Homo sapiens] [Reaction:110380] Dissociation of LIG3:XRCC1 complex from the BER site [Homo sapiens] [Reaction:5649724] LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site [Homo sapiens] [Reaction:5651792] LIG1 and POLB dissociate from repaired dsDNA [Homo sapiens]
(physicalEntity) [CatalystActivity:110374] DNA-(apurinic or apyrimidinic site) endonuclease activity of POLB [nucleoplasm] [CatalystActivity:110377] DNA-directed DNA polymerase activity of POLB [nucleoplasm]
(updatedInstance) [_UpdateTracker:9878031] Update Tracker - [EntityWithAccessionedSequence:53845] POLB [nucleoplasm] - v44:[modifyEndCoordinate, modifyStartCoordinate] [_UpdateTracker:9885692] Update Tracker - [EntityWithAccessionedSequence:53845] POLB [nucleoplasm] - v45:[addName] [_UpdateTracker:9939998] Update Tracker - [EntityWithAccessionedSequence:53845] POLB [nucleoplasm] - v92:[modifyStartCoordinate]
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Pathways
No pathways have been reviewed or authored by POLB [nucleoplasm] (53845)