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Details on Person UniProt:O94777 DPM2
| Class:Id | ReferenceGeneProduct:53838 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-84 added on Fri February 6 2015;initiator methionine:1 for 53838 removed on Fri Nov 03 2023;initiator methionine: for 53838 added on Fri Nov 03 2023;initiator methionine: for 53838 removed on Fri Aug 15 2025;initiator methionine:1 for 53838 added on Fri Aug 15 2025 |
| _displayName | UniProt:O94777 DPM2 |
| _timestamp | 2025-08-15 22:07:29 |
| chain | initiator methionine:1 chain:2-84 |
| checksum | 0247A0843A711EE9 |
| comment | FUNCTION Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:10835346). Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:10835346). Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815). May act by regulating the GPI-GNT complex (PubMed:10944123).PATHWAY Protein modification; protein glycosylation.SUBUNIT Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3 (PubMed:10835346). Component of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2 (PubMed:16162815). Interacts with PIGA, PIGC and PIGQ (PubMed:10944123).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the DPM2 family. |
| description | recommendedName: fullName evidence="9"Dolichol phosphate-mannose biosynthesis regulatory protein alternativeName: Dolichol-phosphate mannose synthase subunit 2 shortName: DPM synthase subunit 2 |
| geneName | DPM2 My026 |
| identifier | O94777 |
| isSequenceChanged | FALSE |
| keyword | Congenital disorder of glycosylation Congenital muscular dystrophy Direct protein sequencing Disease variant Dystroglycanopathy Endoplasmic reticulum Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DPM2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993000] ENSEMBL:ENSG00000136908 DPM2 [Homo sapiens] |
| secondaryIdentifier | DPM2_HUMAN Q5XKK9 Q6FGH3 |
| sequenceLength | 84 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:162689] DPM2 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:4719378] DPM2 Y23C [endoplasmic reticulum membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:4719393] L-tyrosine 23 replaced with L-cysteine |
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No pathways have been reviewed or authored by UniProt:O94777 DPM2 (53838)
