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Details on Person UniProt:Q9C005 DPY30
| Class:Id | ReferenceGeneProduct:53818 |
|---|---|
| _chainChangeLog | chain:1-99 added on Fri February 6 2015 |
| _displayName | UniProt:Q9C005 DPY30 |
| _timestamp | 2024-11-03 19:55:57 |
| chain | chain:1-99 |
| checksum | 5356AC515B9C2ADB |
| comment | FUNCTION As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.SUBUNIT Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ASH2L; the interaction is direct. Interacts with ARFGEF1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.INTERACTION Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity).SIMILARITY Belongs to the dpy-30 family. |
| description | recommendedName: Protein dpy-30 homolog alternativeName: Dpy-30-like protein shortName: Dpy-30L |
| geneName | DPY30 |
| identifier | Q9C005 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Chromatin regulator Golgi apparatus Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DPY30 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962357] ENSEMBL:ENSG00000162961 DPY30 [Homo sapiens] |
| secondaryIdentifier | DPY30_HUMAN D6W578 |
| sequenceLength | 99 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5669104] DPY30 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9966765] DPY30 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969406] DPY30 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9C005 DPY30 (53818)
