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Details on Person UniProt:Q00765 REEP5
| Class:Id | ReferenceGeneProduct:53816 |
|---|---|
| _chainChangeLog | chain:1-189 added on Sat February 7 2015 |
| _displayName | UniProt:Q00765 REEP5 |
| _timestamp | 2024-11-03 19:38:29 |
| chain | chain:1-189 |
| checksum | F4E57E500CB7C831 |
| comment | FUNCTION Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.SUBUNIT Monomer (PubMed:32075961). Homodimer; maybe disulfide-linked (PubMed:32075961). Homotrimer (By similarity). Interacts with ATL1 (By similarity). Interacts with ATL2 (PubMed:19665976). Interacts with ATL3 (PubMed:32075961). Interacts with CKAP4 (PubMed:32075961). Interacts with RTN4 (isoforms A and B) (PubMed:32075961). Interacts with ZFYVE27 (PubMed:23969831).INTERACTION Localizes to endoplasmic reticulum tubular network (PubMed:23969831). In cardiomyocytes, localizes to the junctional sarcoplasmic reticulum membrane which is closely tethered to the cell membrane and contractile machinery (By similarity).ALTERNATIVE PRODUCTS Expressed in heart (at protein level) (PubMed:32075961). Expressed in circumvallate papillae and testis (PubMed:16720576).DOMAIN The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.SIMILARITY Belongs to the DP1 family. |
| description | recommendedName: Receptor expression-enhancing protein 5 alternativeName: Polyposis locus protein 1 alternativeName: Protein TB2 |
| geneName | REEP5 C5orf18 DP1 TB2 |
| identifier | Q00765 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Endoplasmic reticulum Membrane Proteomics identification Reference proteome Sarcoplasmic reticulum Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | REEP5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003765] ENSEMBL:ENSG00000129625 REEP5 [Homo sapiens] |
| secondaryIdentifier | REEP5_HUMAN B7Z681 D3DT04 Q04198 Q5QGT0 Q9BWH9 |
| sequenceLength | 189 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968965] UniProt:Q00765-1 REEP5 [Homo sapiens] [ReferenceIsoform:8968966] UniProt:Q00765-2 REEP5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8939745] REEP5 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q00765 REEP5 (53816)
