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Details on Person UniProt:P18858 LIG1
| Class:Id | ReferenceGeneProduct:53788 |
|---|---|
| _chainChangeLog | chain:1-919 added on Sat February 7 2015 |
| _displayName | UniProt:P18858 LIG1 |
| _timestamp | 2024-11-03 19:55:56 |
| chain | chain:1-919 |
| checksum | B2854DAE38A8D4AD |
| comment | FUNCTION DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination.CATALYTIC ACTIVITY ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.COFACTOR Interacts with PCNA (PubMed:24911150). Interacts with POLB (PubMed:19336415).SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ATP-dependent DNA ligase family.ONLINE INFORMATION LIG1 mutation dbONLINE INFORMATION DNA ligase entry |
| description | recommendedName: DNA ligase 1 ecNumber evidence="2"6.5.1.1 alternativeName: DNA ligase I alternativeName: Polydeoxyribonucleotide synthase [ATP] 1 |
| geneName | LIG1 |
| identifier | P18858 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Disease variant DNA damage DNA recombination DNA repair DNA replication Ligase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LIG1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990077] ENSEMBL:ENSG00000105486 LIG1 [Homo sapiens] |
| secondaryIdentifier | DNLI1_HUMAN B2RAI8 B4DTU4 Q2TB12 Q32P23 |
| sequenceLength | 919 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976973] UniProt:P18858-1 LIG1 [Homo sapiens] [ReferenceIsoform:8976974] UniProt:P18858-2 LIG1 [Homo sapiens] [ReferenceIsoform:8976975] UniProt:P18858-3 LIG1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P18858 LIG1 (53788)
